Mechanism of peripheral noradrenergic stimulation by clozapine.

Elevated plasma norepinephrine (NE) levels is a relatively consistent clinical effect of clozapine. Plasma NE levels reflect an interplay of release, reuptake, metabolism, and excretion. To explore the mechanism of clozapine-induced plasma NE elevation, we measured arterial plasma levels of NE and other catechols during intravenous infusion of tritium-labeled NE (3H-NE) in schizophrenic patients treated with clozapine, fluphenazine, or placebo.

Clinical evaluation of a composite resin system with a dentin bonding agent for restoration of permanent posterior teeth: a 3-year study.

This study evaluated the clinical performance of a visible light-cured small particle bimodally filled hybrid condensable composite resin system that included a dentin bonding agent compared with an amalgam alloy in class II restorations of permanent teeth. A total of 108 restorations were placed in 34 patients. Fifty-three composite resin and 55 amalgam restorations were inserted.

Clinical management of multiple maxillary anterior supernumerary teeth: report of case.

Supernumerary teeth in the maxillary midline can present both esthetic and pathologic concerns that can be difficult to solve. The frequency with which supernumerary teeth occur justifies an oral radiographic survey for preschool children as early detection is most important, if such complications are to be avoided or minimized. The case presented in this report required both surgical and innovative orthodontic therapy to bring an unerupted, impacted maxillary central incisor into proper alignment.

Measurement of regional neuronal removal of norepinephrine in man.

We describe here and validate an in vivo technique to measure the regional proportionate removal of norepinephrine (NE) by neuronal uptake (Uptake1) in man. The measurement is based on the steady-state arterial and venous concentrations of tritiated NE and tritiated isoproterenol (ISO) during simultaneous infusion of both. The validity of this technique depends on the removal of circulating NE, but not of ISO, by sympathetic nerve endings and on there being no other factor contributing to the net difference in the plasma disappearance of these catecholamines.

Orthodontic therapy in patients with juvenile periodontitis: clinical and microbiologic effects.

The correction of malocclusions in juvenile periodontitis (JP) patients completing periodontal therapy is a problem of increasing clinical concern to orthodontists, since many teeth with severe alveolar bone loss in these patients can now be successfully treated without extraction. In this report, fixed edgewise orthodontic therapy was carried out after the completion of periodontal therapy on four JP patients. The orthodontic therapy included extensive intrusion of teeth severely affected by JP.

Dental root agenesis secondary to irradiation therapy in a case of rhabdomyosarcoma of the middle ear.

There have been only a few published reports on the dental-facial effects of radiation therapy and the subsequent oral management of these patients. A case involving a 13-year-old black male patient with a history of rhabdomyosarcoma is presented. The patient received 4,050 rads of radiation to the right middle ear when he was 2 years of age.

Compatibility of various materials with oral tissues. II: Pulp responses to composite ingredients.

Eight ingredients of composite materials were evaluated individually for pulp irritation. None caused significant inflammation as evidenced by its average response. No abscess formations or lesions predominating in leukocytes occurred.

Radiographic detectability of occipital and temporal-parietal fractures induced in cadaver heads.

Diagnostic performance based on a double-blind evaluation of test and control radiographs produced from nine different fractured cadaver skulls was compiled for six radiologists. The data resulting from two different diagnostic tasks were analyzed statistically for accuracy and confirmed interpretability including an assessment of task-related performance differences. Performance was found to be relatively independent of differences among radiologists and lesion location.