Publications by authors named "Folasade A Sofela"
Intellectual disability is defined as limitations in cognitive and adaptive behavior that often arise during development. Disordered sleep is common in intellectual disability and, given the importance of sleep for cognitive function, it may contribute to other behavioral phenotypes. Animal models of intellectual disability, in particular of monogenic intellectual disability syndromes (MIDS), recapitulate many disease phenotypes and have been invaluable for linking some of these phenotypes to specific molecular pathways.
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- - The study investigates how the growth and remodeling of dural cerebral veins (CV) in mammals is regulated, linking these processes to cerebrospinal fluid absorption and brain health.
- - Researchers found that mutations in the TWIST1 gene, associated with craniosynostosis, lead to venous malformations, which they replicated in mouse models; surprisingly, TWIST1 isn't needed in endothelial cells but is crucial for the development of bone-forming cells (preosteoblasts).
- - The disruption of bone morphogenetic proteins (BMPs) from preosteoblasts and dura was shown to cause skull and CV defects, while arterial development remained unaffected, suggesting that signals from the skull and dura create the necessary conditions for