Publications by authors named "Foddha Abdelhak"

Background: ​Vascular endothelial growth factor A (VEGFA) is well acknowledged as a powerful angiogenesis-promoting agent mainly through its receptor VEGFR2. Ischemia stimulates VEGFA/VEGFR2 signaling pathway and elevated serum levels of VEGFA were detected in coronary heart disease (CHD) patients. The goal of the current study is to determine how four SNPs in the genes for VEGFA (rs3025039 and rs699947) and VEGFR2 (rs2305948 and rs1870377) contribute to the development of CHD.

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Article Synopsis
  • Coronary artery disease (CAD) can lead to myocardial infarction (MI), which increases the risk of sudden cardiac death (SCD) and ventricular arrhythmias (VA).
  • The study aimed to link specific genetic variations (SNPs) in genes related to heart arrhythmias with the likelihood of developing VA during an MI.
  • Results indicated that two SNPs, specifically in the SCN5A and SCN10A genes, were significantly connected to a higher risk of VA in MI patients, which could potentially help in predicting and preventing SCD.
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