Quality of Life in Patients and Their Spouses and Cohabitating Partners in the Year Following a Cancer Biopsy (the Couples Cope Study): Protocol for a Prospective Observational Study.

Background: Receiving a diagnosis of cancer is a profound and often very stressful experience. Few studies have prospectively recruited patients prior to receiving a new diagnosis of cancer and included spouses or partners.

Objective: The aim of the Couples Cope Study is to understand the impact of undergoing a diagnostic biopsy and receiving a new cancer diagnosis on quality of life (QoL) in both patients and their spouses or partners, as well as on the quality of their relationship.

Age and 17β-Estradiol (E) Facilitate Nuclear Export and Argonaute Loading of microRNAs in the Female Brain.

Aging in women is accompanied by a dramatic change in circulating sex steroid hormones. Specifically, the primary circulating estrogen, 17β-estradiol (E), is nearly undetectable in post-menopausal women. This decline is associated with a variety of cognitive and mood disorders, yet hormone replacement therapy is only effective within a narrow window of time surrounding the menopausal transition.

Indirect repair of saliva-contaminated materials using veneering ceramics.

Purpose: To analyze the in vitro efficacy of a surface conditioning liquid facilitating ceramic repairs of saliva-contaminated metal-ceramic and all-ceramic restorations.

Materials And Methods: Specimens constructed from nonprecious alloy (NPA), precious alloy (PA), lithium-disilicate (LD), zirconia (ZI), veneering ceramics for zirconia (VZI), veneering ceramics for lithium-disilicate (VLD), and veneering ceramics for metal alloys (VM) were manufactured (total: n = 168; each material n = 24). Veneering ceramic cylinders (thickness: 2 mm) were hand-layered on top of the specimens.

Symptom burden profiles in men with advanced prostate cancer undergoing androgen deprivation therapy.

To identify symptom burden profiles among men with advanced prostate cancer undergoing androgen-deprivation therapy and examine their association with baseline sociodemographic and medical characteristics and psychosocial outcomes over time. Latent profile analysis was employed to identify distinct groups based on the Expanded Prostate Index Composite and the McGill Pain Questionnaire at baseline. Psychosocial outcomes were assessed at baseline, 6- and 12-month follow-ups.

17β-Estradiol Regulates miR-9-5p and miR-9-3p Stability and Function in the Aged Female Rat Brain.

Clinical studies demonstrated that the ovarian hormone 17β-estradiol (E) is neuroprotective within a narrow window of time following menopause, suggesting that there is a biological switch in E action that is temporally dependent. However, the molecular mechanisms mediating this temporal switch have not been determined. Our previous studies focused on microRNAs (miRNA) as one potential molecular mediator and showed that E differentially regulated a subset of mature miRNAs which was dependent on age and the length of time following E deprivation.

Absolute Quantification of Phosphorylated ERβ Amino Acids in the Hippocampus of Women and in A Rat Model of Menopause.

The rapid decline of circulating 17β-estradiol (E2) at menopause leads to negative neurological consequences, although hormone therapy paradoxically has both harmful and positive effects depending on the age at which it is delivered. The inconsistent response to E2 suggests unappreciated regulatory mechanisms for estrogen receptors (ERs), and we predicted it could be due to age-related differences in ERβ phosphorylation. We assessed ERβ phosphorylation using a sensitive mass spectrometry approach that provides absolute quantification (AQUA-MS) of individually phosphorylated residues.

Restoration of teeth affected by molar-incisor hypomineralisation: a systematic review.

The objective was to systematically analyse clinical studies on restorative procedures for teeth affected by molar-incisor hypomineralisation (MIH). The databases PubMed, Embase, and Cochrane Library were searched. Only retrospective and prospective clinical studies dealing with sealing or restoration of MIH-affected teeth were included.

Effects of web-based cognitive behavioral stress management and health promotion interventions on neuroendocrine and inflammatory markers in men with advanced prostate cancer: A randomized controlled trial.

Unlabelled: Cognitive behavioral stress management (CBSM) improves quality of life and mitigates stress biology in patients with early-stage cancer, including men with localized prostate cancer. However, treatments for advanced prostate cancer like androgen deprivation therapy (ADT) can lead to significant symptom burden that may be further exacerbated by stress-induced inflammation and cortisol dysregulation. The aim of this study was to examine the effects of CBSM (versus an active health promotion control) on circulating inflammatory markers and cortisol in men with advanced prostate cancer.

Reentry of endodontic access cavities: composite residue and loss of tooth substance.

The purpose of this study was to investigate the ability of dentists to remove composite fillings from endodontic access cavities using illumination from a conventional light source (CLS) versus the fluorescence-aided identification technique (FIT) in terms of completeness, selectivity and treatment duration. Therefore, two independent operators removed composite resin from six sets of root-filled incisors in a maxillary model under simulated clinical conditions using the CLS or FIT method (twelve teeth per operator and technique). The duration of treatment was recorded and before-after micro-CT scans were superimposed for volumetric assessment of treatment completeness and selectivity.

[Single tufted brushes – what about the quality of the bristles?].

Cleaning with individual tufted brushes can be used as a supplement wherever a regular toothbrush is unable to reach areas in the mouth. in the mouth. For example, single-tufted brushes are suitable for cleaning brackets and bands as well as adjacent teeth during fixed orthodontic treatment.

Technology-Based Psychosocial Intervention to Improve Quality of Life and Reduce Symptom Burden in Men with Advanced Prostate Cancer: Results from a Randomized Controlled Trial.

Background: Men with advanced prostate cancer (APC) face multiple challenges including poor prognosis, poor health-related quality of life (HRQOL), and elevated symptom burden. This study sought to establish the efficacy of a tablet-delivered, group-based psychosocial intervention for improving HRQOL and reducing symptom burden in men with APC. We hypothesized that men randomized to cognitive-behavioral stress management (CBSM) would report improved HRQOL and reduced symptom burden relative to men randomized to an active control health promotion (HP) condition.

Quantitative evaluation of the progressive wear of powered interproximal reduction systems after repeated use : An in vitro study.

Purpose: To evaluate the residual surface roughness of 5 common diamond-coated interproximal reduction (IPR) systems after consecutive in vitro applications in relation to system, diamond grain size, and instrument thickness.

Methods: IPR was performed on 80 extracted human incisors using motor-driven strips and discs under predefined conditions. The IPR auxiliaries were applied at 5 consecutive sessions of 20 s on intact interproximal surfaces, and the surface profile (R, R, R) was analyzed at baseline and after each session with an optical profilometer.

Dynamic Relay of Protein-Bound Lipoic Acid in Staphylococcus aureus.

competes for myriad essential nutrients during host infection. One of these nutrients is the organosulfur compound lipoic acid, a cofactor required for the activity of several metabolic enzyme complexes. In , these include the E2 subunits of three α-ketoacid dehydrogenases and two H proteins, GcvH of the glycine cleavage system and its paralog, GcvH-L.

Repair bond strength of resin composite to restorative materials after short- and long-term storage.

Objectives: To investigate short- and long-term bond strength ("repair bond strength"; RBS) of a resin composite to six restorative materials using either a silane and a bonding agent or a universal "one-step self-etch" adhesive system.

Methods: Specimens were produced from an amalgam, a direct resin composite, two indirect resin composites, a hybrid ceramic, and a feldspar ceramic and stored for 3 months in tap water (37 °C). All specimens were then sandblasted (AlO; 25 μm) and either treated with Monobond Plus and OptiBond FL Adhesive (MP-OFL) or with Scotchbond Universal (SBU).

Integrating PROMIS® computerized adaptive tests into a web-based intervention for prostate cancer.

Objective: This study outlined the implementation and feasibility of delivering PROMIS® computer adaptive tests (CATs) using a web-based method to evaluate the impact of a technological adaptation of Cognitive-Behavioral Stress Management (CBSM) on the psychosocial functioning of men with advanced prostate cancer (APC) undergoing hormone therapy.

Method: Patients were randomized to a CBSM group intervention (n = 95) or a health promotion (HP) attention-matched control condition (n = 97). Participants attended all sessions via video conference using tablets, and completed PROMIS® computer adaptive tests (CATs) assessing anxiety, depression, fatigue, pain interference, and physical function weekly during the 10-week intervention.

Brief report of a tablet-delivered psychosocial intervention for men with advanced prostate cancer: Acceptability and efficacy by race.

Relative to non-Hispanic whites (NHW), black men are disproportionately affected by prostate cancer (PC) incidence, have poorer PC outcomes, and report greater compromises in health-related quality of life. Despite these challenges, black men are underrepresented in psychosocial cancer research, possibly due to limited access to supportive oncology programs. The purpose of this article is to examine the acceptability and efficacy for reducing disease-specific distress of a tablet-delivered psychosocial intervention for older men with advanced PC (APC) and explore differences by race.

The Effect of SnCl/AmF Pretreatment on Short- and Long-Term Bond Strength to Eroded Dentin.

This study investigated the effect of SnCl/AmF pretreatment on short- and long-term bond strength of resin composite to eroded dentin mediated by two self-etch, MDP-containing adhesive systems. 184 dentin specimens were produced from extracted human molars. Half the specimens ( = 92) were artificially eroded, and half were left untreated.

Increased flexibility in the use of exogenous lipoic acid by Staphylococcus aureus.

Lipoic acid is a cofactor required for intermediary metabolism that is either synthesized de novo or acquired from environmental sources. The bacterial pathogen Staphylococcus aureus encodes enzymes required for de novo biosynthesis, but also encodes two ligases, LplA1 and LplA2, that are sufficient for lipoic acid salvage during infection. S.

The phantom midge menace: Migratory Chaoborus larvae maintain poor ecosystem state in eutrophic inland waters.

Chaoborus spp. (phantom midge) are prevalent in eutrophic inland waters. In Lake Soppen, Switzerland, C.

Cutaneous Lesions of the External Genitalia.

Individuals with cutaneous diseases of the external genitalia often initially present to their primary care provider. When present, these conditions may be associated with considerable physical symptoms and psychological distress. Dermatoses affecting the genitals may be of infectious, inflammatory, or neoplastic cause, and can be processes confined to the genitalia or a manifestation of a more widespread dermatologic condition.

[(How) can progression of chronic kidney diseases be retarded?].

(How) can progression of chronic kidney diseases be retarded? Abstract. A variety of etiologically diverse chronic kidney diseases (CKD) may not only progress to end stage renal disease, but also increase cardiovascular morbidity and overall mortality. Once a critical mass of renal tissue has been irreversibly scarred, maladaptive mechanisms lead to progressive loss of the remaining kidney tissue, independent of the initial mechanism causing kidney injury.

Full-scale evaluation of methane production under oxic conditions in a mesotrophic lake.

Oxic lake surface waters are frequently oversaturated with methane (CH). The contribution to the global CH cycle is significant, thus leading to an increasing number of studies and stimulating debates. Here we show, using a mass balance, on a temperate, mesotrophic lake, that ~90% of CH emissions to the atmosphere is due to CH produced within the oxic surface mixed layer (SML) during the stratified period, while the often observed CH maximum at the thermocline represents only a physically driven accumulation.