Publications by authors named "Fluege T"
Antioxid Redox Signal
April 2015
Article Synopsis
- Mitochondrial thioredoxin reductase (Txnrd2) regulates hydrogen peroxide levels and plays a crucial role in tumor growth by impacting Hif-1α signaling, VEGF levels, and tumor vascularization.
- Tumor cells lacking Txnrd2 showed increased PHD2 levels and reduced Hif-1α signaling, leading to decreased tumor growth due to enhanced JNK activation and changes in the mitochondrial redox state.
- The study identifies a new regulatory mechanism involving Txnrd2, suggesting that targeting both mitochondrial thioredoxin and glutathione systems could be an effective strategy for cancer therapy.
