Publications by authors named "Florica J G Opoc"
Article Synopsis
- Non-genetic variations in gene expression can lead to differences between cells in the same population, known as cell-to-cell heterogeneity.
- While cells typically work to minimize this variability, it can sometimes offer advantages in certain environments, though the specific molecular pathways controlling this "noise" are not fully understood.
- In a study using yeast, researchers discovered that the histone deacetylase Hos2 acts as a negative regulator of expression noise, influencing protein translation by down-regulating certain ribosomal protein genes, demonstrating new insights into how cells manage non-genetic variations.
The discrete steps of transcriptional rewiring have been proposed to occur neutrally to ensure steady gene expression under stabilizing selection. A conflict-free switch of a regulon between regulators may require an immediate compensatory evolution to minimize deleterious effects. Here, we perform an evolutionary repair experiment on the Lachancea kluyveri yeast sef1Δ mutant using a suppressor development strategy.
View Article and Find Full Text PDFThe mitochondrion is an ancient endosymbiotic organelle that performs many essential functions in eukaryotic cells. Mitochondrial impairment often results in physiological defects or diseases. Since most mitochondrial genes have been copied into the nuclear genome during evolution, the regulatory and interaction mechanisms between the mitochondrial and nuclear genomes are very complex.
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