Publications by authors named "Floriano Indino"
Background: Pheochromocytomas and paragangliomas (PPGL) are neuroendocrine tumors that originate from adrenal medulla or extra-adrenal chromaffin cells, respectively. They produce an excess of catecholamines and their metabolites. Abnormal levels of these biomolecules have been also found in pediatric patients with neuroblastoma (NB).
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- The study focused on tracking the viral load in COVID-19 patients using RT-PCR tests on nasopharyngeal swabs to understand outbreak control better.
- About 41 hospitalized patients were analyzed, revealing that 48.8% had severe symptoms while 51.2% presented milder symptoms, with a notable trend where viral load decreased over time after symptom onset.
- High viral loads (Ct of 25) were detected around 9.9 days post-symptom onset, and a majority maintained high levels for over a week, particularly those with severe symptoms, highlighting the need for timely detection and interventions in managing the spread of the virus.
Protection provided by COVID-19 vaccines is compromised due to waning immunity over time. This study aimed to assess the level of antibodies anti-S-RBD of SARS-CoV-2 in a cohort of healthcare workers before and, on average, one and four months after the third dose of the BNT162b2 vaccine. The determination of antibodies was carried out in serum samples using an electrochemiluminescence immunoassay (ECLIA).
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- The BNT162b2 mRNA vaccine was the first approved vaccine during the SARS-CoV-2 pandemic, noted for generating humoral immunity after two doses, but showed a decline in antibody levels over time.
- Following this, a third dose was administered, particularly to vulnerable groups like healthcare workers, to boost antibody concentration.
- A study with 37 healthcare workers revealed a significant increase in antibody levels after the third dose, with younger individuals and women showing higher antibody concentrations compared to older individuals before the booster.