Publications by authors named "Florianne O L Vehmeijer"
While studies suggest potential influences of childhood adversities on obesity development in adulthood, less is known about the short-term association in children. We examined the association between a wide range of life events experienced in the first ten years of life (including maltreatment and milder adversities) and body composition in 5333 ten-year old Dutch children. In structured interviews, mothers retrospectively reported on their children's experience of 24 events.
View Article and Find Full Text PDFContext: Biological stress is related to cardiovascular disease in adults. The associations of stress with cardiovascular and metabolic diseases may originate in childhood.
Objective: This work aims to examine the associations of hair cortisol concentrations at age 6 years with cardiometabolic risk factors at ages 6 and 10 years.
Article Synopsis
- This study investigates how changes in maternal hemoglobin levels during pregnancy might affect offspring DNA methylation, which could have long-term impacts on health.* -
- Researchers conducted a meta-analysis involving nearly 7,500 samples from newborns, children, and adolescents, looking for links between maternal hemoglobin and DNA methylation.* -
- The results showed no significant association between normal maternal hemoglobin levels and offspring DNA methylation, suggesting that effects may occur only at extreme hemoglobin levels.*
Article Synopsis
- DNA methylation in childhood and adolescence shows significant correlations with body mass index (BMI), suggesting potential early indicators of obesity.
- Analysis involved cord blood and whole blood measurements from up to 4,133 children in various studies, indicating the importance of age-specific patterns in dietary and physical health.
- Findings reveal that as children age, the strength of the associations between DNA methylation and BMI increases, emphasizing the potential for using methylation patterns in obesity prevention strategies.
Context: Stress may lead to an adverse body fat distribution from childhood onwards.
Objective: To examine the associations of hair cortisol concentration (HCC) at 6 years with general and organ fat measures, risk of overweight, and nonalcoholic fatty liver disease (NAFLD) at 10 years and to assess whether these were independent of adiposity measures at 6 years.
Design, Setting And Participants: HCCs were measured in hair of 6-year-old children (n = 2042) participating in the Generation R Study, a population-based prospective cohort study.
Background: Psychological distress and inappropriate or excessive weight gain are common in pregnancy and are associated with adverse maternal and offspring outcomes. Psychological well-being and weight status of women during pregnancy might be interrelated. We aimed to examine whether psychological distress during pregnancy is associated with gestational weight gain.
View Article and Find Full Text PDFPsychological distress during pregnancy may influence offspring adiposity. No studies assessed the associations with organ fat measures. We examined the associations of maternal psychological distress, depression, and anxiety during pregnancy with child general and organ fat measures.
View Article and Find Full Text PDFPurpose: Anti-epileptic drugs (AEDs) and the ketogenic diet (KD) are often used concomitantly in children with refractory epilepsy. It has been hypothesised that certain AEDs may interfere with KD. The purpose of this study was to elucidate relationships between efficacy of KD and use of specific AEDs.
View Article and Find Full Text PDFBackground: The ketogenic diet (KD) can be effective in reducing seizures in children. Predictors of success have not been identified yet.
Aims: To evaluate efficacy of KD treatment and to search for child- or diet-related factors that can predict its efficacy at 12 months follow-up.