Loss of anterior gradient-2 expression is an independent prognostic factor in colorectal carcinomas.

Aims: The human Anterior Gradient-2 (AGR2) protein is strongly expressed in various human cancers, and it has been described to promote aggressive tumour features in some entities. So far, a comprehensive analysis of AGR2 expression in colorectal carcinomas has not been described.

Methods: Normal intestinal cells and colorectal carcinoma cell lines were analysed for AGR2 expression.