Cancer Risks Associated With and Pathogenic Variants.

Purpose: To provide precise age-specific risk estimates of cancers other than female breast and ovarian cancers associated with pathogenic variants (PVs) in and for effective cancer risk management.

Methods: We used data from 3,184 and 2,157 families in the Consortium of Investigators of Modifiers of to estimate age-specific relative (RR) and absolute risks for 22 first primary cancer types adjusting for family ascertainment.

Results: PVs were associated with risks of male breast (RR = 4.

Cancer Spectrum, Family History of Cancer and Overall Survival in Men with Germline or Mutations.

Background: Men with germline mutations are not well studied compared to their female counterparts. This study evaluates the cancer characteristics, family history of cancer, and outcomes of male mutation carriers.

Methods: All men with germline / mutations who attended genetic assessment between October 1995 and October 2019 at the Medical University of Vienna were identified.