Biphasic Calcium Phosphate and Activated Carbon Microparticles in a Plasma Clot for Bone Reconstruction and In Situ Drug Delivery: A Feasibility Study.

The development of bone-filling biomaterials capable of delivering in situ bone growth promoters or therapeutic agents is a key area of research. We previously developed a biomaterial constituting biphasic calcium phosphate (BCP) microparticles embedded in an autologous blood or plasma clot, which induced bone-like tissue formation in ectopic sites and mature bone formation in orthotopic sites, in small and large animals. More recently, we showed that activated carbon (AC) fiber cloth is a biocompatible material that can be used, due to its multiscale porosity, as therapeutic drug delivery system.

Activated Carbon Fiber Cloth/Biomimetic Apatite: A Dual Drug Delivery System.

A biomaterial that is both bioactive and capable of controlled drug release is highly attractive for bone regeneration. In previous works, we demonstrated the possibility of combining activated carbon fiber cloth (ACC) and biomimetic apatite (such as calcium-deficient hydroxyapatite (CDA)) to develop an efficient material for bone regeneration. The aim to use the adsorption properties of an activated carbon/biomimetic apatite composite to synthetize a biomaterial to be used as a controlled drug release system after implantation.

Proteomic analysis identified LBP and CD14 as key proteins in blood/biphasic calcium phosphate microparticle interactions.

Immediately upon implantation, scaffolds for bone repair are exposed to the patient's blood. Blood proteins adhere to the biomaterial surface and the protein layer affects both blood cell functions and biomaterial bioactivity. Previously, we reported that 80-200 µm biphasic calcium phosphate (BCP) microparticles embedded in a blood clot, induce ectopic woven bone formation in mice, when 200-500 µm BCP particles induce mainly fibrous tissue.

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Introduction: Access to palliative care is a right recognized in France since 1999. Various care systems are present in the field of palliative care, and in particular the Identified Palliative Care Beds (LISP), which aim to promote the deployment of the palliative culture and approach in care services regularly confronted with palliative situations and whose organizational reference framework is mentioned in DHOS/O2/2008/99 of 25 March 2008. Although the system is widely deployed in hospitals, there is still some uncertainty about the actual functioning of LISPs and the impact of the system on these initial objectives.

Nanostructured Thermal Responsive Materials Synthesized by Soft Templating.

We capitalized herein the inherent tortuosity of bicontinuous microemulsion to conceive nanostructured drug-delivery devices. First, we show that it is possible to synthesize bicontinuous materials with continuous hydrophilic domains of the poly(N-isopropylacrylamide) (PNIPAM) network entangled with continuous hydrophobic polymer domains, with dual-phase continuity being imposed by the bicontinuous microemulsions used as a soft template. Particular attention is paid to the microemulsion formulations using a surfmer to preserve the one-to-one replication of the bicontinuous nanostructure after polymerization.