Publications by authors named "Florian Lejuste"
Article Synopsis
- - Autism spectrum disorder (ASD) is marked by challenges in social communication and repetitive behaviors, with maternal immune activation (MIA) during mid-pregnancy identified as a risk factor, affecting about 15% of those with ASD.
- - This study hypothesized that individuals with ASD who experienced MIA would show greater socio-adaptive impairments compared to those without, analyzing data from 295 mother-child pairs, with findings indicating more severe socialization difficulties in the ASD-MIA group.
- - Limitations of the study include its retrospective nature and a relatively small sample size, underscoring the need for larger prospective studies to explore the specific biological mechanisms behind the socio-adaptive challenges in ASD-MIA individuals.
Background: While adult outcome in autism spectrum disorder (ASD) is generally measured using socially valued roles, it could also be understood in terms of aspects related to health status - an approach that could inform on potential gender differences.
Methods: We investigated gender differences in two aspects of outcome related to health-status, i.e.
Autism spectrum disorder (ASD) represents a set of heterogeneous neurodevelopmental conditions defined by impaired social interactions and repetitive behaviors. The number of reported cases has increased over the past decades, and ASD is now a major public health burden. So far, only treatments to alleviate symptoms are available, with still unmet need for an effective disease treatment to reduce ASD core symptoms.
View Article and Find Full Text PDFAutism spectrum disorder (ASD) is a very heterogeneous disorder. Obsessive compulsive disorder (OCD) comorbidity, frequent in ASD, could be useful to define a specific ASD subtype. Our objective was to explore if adults with ASD and comorbid OCD could present a specific clinical profile of ASD in 89 high functioning-adult ASD patients.
View Article and Find Full Text PDFAutism Spectrum Disorders (ASDs) are neurodevelopmental disorders defined by impaired social interactions and communication with repetitive behaviors, activities, or interests. Gastrointestinal (GI) disturbances and gut microbiota dysbiosis are frequently associated with ASD in childhood. However, it is not known whether microbiota dysbiosis in ASD patients also occurs in adulthood.
View Article and Find Full Text PDFFrom the microscope to the magnet: Disconnection in schizophrenia and bipolar disorder.
Neurosci Biobehav Rev
March 2019
Article Synopsis
- - The article reviews studies on white matter abnormalities in schizophrenia (SZ) and bipolar disorder (BD), aiming to determine whether these issues are shared between the two conditions or distinct to each.
- - Most research indicates no significant differences in white matter changes between SZ and BD, highlighting common alterations in brain structures such as the thalamic radiations and corpus callosum, as well as cellular changes like oligodendrocyte density and myelin staining.
- - The integration of neuroimaging and neuropathological methods suggests that both disorders exhibit shared disconnectivity, emphasizing the importance of focusing on clinical features rather than solely on specific diagnoses for better understanding and prevention strategies.
Neuroleptic intolerance in patients with anti-NMDAR encephalitis.
Neurol Neuroimmunol Neuroinflamm
October 2016
Objective: To precisely describe the initial psychiatric presentation of patients with anti-NMDA receptor (NMDAR) antibodies encephalitis (anti-NMDAR encephalitis) to identify potential clues enhancing its early diagnosis.
Methods: We retrospectively studied the French Reference Centre medical records of every adult patient with anti-NMDAR encephalitis to specify the patients' initial psychiatric symptoms leading to hospitalization in a psychiatric department and the reasons underlying the diagnosis of anti-NMDAR encephalitis.
Results: The medical records of 111 adult patients were reviewed.