Publications by authors named "Florian Koroska"
Comparison of nine different selective agars for the detection of carbapenemase-producing Enterobacterales (CPE).
Eur J Clin Microbiol Infect Dis
May 2020
Article Synopsis
- * Out of 69 CPE and 40 non-CPE isolates tested, Brilliance CRE and McCARB/McCARB-T showed the highest sensitivity in identifying CPE, particularly OXA-48 producers which were challenging to detect.
- * It was concluded that while some agars excelled in sensitivity, ESBL agars alone were ineffective for detecting CPE, and using a combination of CRE and ESBL agars yielded the best results.
OXA-48 is the most prevalent carbapenemase in in Europe and the Middle East, but it is frequently missed because many isolates display low MICs for carbapenems. Furthermore, in contrast to metallo-β-lactamases or carbapenemases (KPC), no specific inhibitor is available for the phenotypic detection of OXA-48. Molecular detection of is the "gold standard" but is not available in many laboratories.
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