Publications by authors named "Florian Hoff"
A highly specific transport and sorting machinery directing secretory cargo to the apical or basolateral plasma membrane maintains the characteristic polarized architecture of epithelial cells. This machinery comprises a defined set of transport carriers, which are crucial for cargo delivery to the correct membrane domain. Each carrier is composed of a distinct set of proteins to verify precise routing and cargo selection.
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- COPII-coated vesicles help move proteins from the endoplasmic reticulum (ER) to a part of the cell called the Golgi.
- Scientists discovered that a protein called Sec16 changes when T-cells are activated, which helps the cell adapt to send more proteins when needed.
- This research shows that different forms of Sec16 can control how effectively COPII moves materials, linking changes in the cell’s environment to how proteins are secreted.
Aqueous Viscum album L. extracts are widely used in complementary cancer medicine. Hydrophobic triterpene acids also possess anti-cancer properties, but due to their low solubility they do not occur in significant amounts in aqueous extracts.
View Article and Find Full Text PDFIn epithelial cells apical proteins are transported by specific transport carriers to the correct membrane domain. The composition of these carriers is heterogeneous and comprises components such as motor proteins, annexins, lectins, Rab GTPases and cargo molecules. Here, we provide biochemical and fluorescence microscopic data to show that the dynamin-related large GTPase Mx1 is a component of post-Golgi vesicles carrying the neurotrophin receptor p75(NTR) .
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