Publications by authors named "Florian H Schmidt"

Objective: The current study aims to investigate whether objective measurements of the cochlear nerve (CN), derived from preoperative MRI images, correlate with postoperative speech perception in CI patients.

Study Design: Retrospective cohort study.

Setting: University Medical Center, tertiary academic referral center.

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Purpose: Patients with age-related hearing loss complain often about reduced speech perception in adverse listening environment. Studies on animals have suggested that cochlear synaptopathy may be one of the primary mechanisms responsible for this phenomenon. A decreased wave I amplitude in supra-threshold auditory brainstem response (ABR) can diagnose this pathology non-invasively.

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Objective: Accurate positioning of the electrode array during cochlear implant (CI) surgery is crucial for achieving optimal hearing outcomes. Traditionally, postoperative radiological imaging has been used to assess electrode position. Transimpedance matrix (TIM) measurements have also emerged as a promising method for assessing electrode position.

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Among hearing aid (HA) users, there is a considerable variability in word recognition scores (WRSs). This variability is most pronounced among individuals with moderately severe to severe hearing loss. The variability cannot be adequately explained by factors such as pure-tone audiogram, audiogram type or age.

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Article Synopsis
  • The eukaryotic nucleus is surrounded by a nuclear envelope with nuclear pore complexes (NPCs) that allow for transport between the nucleus and cytoplasm, made up of around 1000 proteins from about 30 different nucleoporins.
  • The architecture of the NPC is dynamic, capable of changing shape in response to external forces, which complicates efforts to understand its function at a detailed structural level.
  • Recent advancements in structural biology, including in situ techniques and proteomic analysis, are helping researchers create more accurate models of the NPC, despite challenges like relying on structures from different species.
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Loudness context effects comprise differences in judgments of the loudness of a target stimulus depending on the presence of a preceding inducer tone. Interstimulus intervals (ISIs) between inducer tone and target tone of about 200 ms and above cause an induced loudness reduction (ILR) of the target tone. As the ILR increases, respectively, the perceived loudness of the target stimuli decreases with increasing ISI.

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