Publications by authors named "Florian Gobet"
Article Synopsis
- Elevated arginase 1 activity leads to a depletion of extracellular arginine, which negatively impacts T cell function and serves as an immunosuppressive mechanism in tumors.
- The mitochondrial arginase isoform Arg2, expressed in T cells, plays a critical role in regulating CD8+ T cell activity and enhancing their tumor-fighting abilities.
- Deleting Arg2 in CD8+ T cells enhances their activation and effectiveness against tumors, especially when combined with PD-1 blockade, suggesting that targeting Arg2 could be a promising strategy for improving cancer immunotherapy.
Evidence has recently emerged that butyrophilins, which are members of the extended B7 family of co-stimulatory molecules, have diverse functions in the immune system. We found that the human and mouse genes encoding butyrophilin-2A2 (BTN2A2) are regulated by the class II trans-activator and regulatory factor X, two transcription factors dedicated to major histocompatibility complex class II expression, suggesting a role in T cell immunity. To address this, we generated Btn2a2-deficient mice.
View Article and Find Full Text PDFBecause of their unique capacity to cross-present Ags to CD8(+) T cells, mouse lymphoid tissue-resident CD8(+) dendritic cells (DCs) and their migratory counterparts are critical for priming antiviral T cell responses. High expression of the dsRNA sensor TLR3 is a distinctive feature of these cross-presenting DC subsets. TLR3 engagement in CD8(+) DCs promotes cross-presentation and the acquisition of effector functions required for driving antiviral T cell responses.
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