Publications by authors named "Florian Demel"
Article Synopsis
- mTORC1 is a key regulator of macrophage functions, affecting their growth and metabolism, but its exact biochemical processes are still being explored.
- The study uses a multiomics approach combined with a modeling technique called COVRECON to find a key biochemical factor that impacts mTORC1-related metabolic profiles in macrophages.
- Tsc2, which inhibits mTORC1, is shown to control the enzyme phosphoglycerate dehydrogenase (Phgdh), revealing its crucial role in macrophage activity and metabolism, particularly influenced by different stimuli like LPS and IL-4.
The aggregation of hypertrophic macrophages constitutes the basis of all granulomatous diseases, such as tuberculosis or sarcoidosis, and is decisive for disease pathogenesis. However, macrophage-intrinsic pathways driving granuloma initiation and maintenance remain elusive. We found that activation of the metabolic checkpoint kinase mTORC1 in macrophages by deletion of the gene encoding tuberous sclerosis 2 (Tsc2) was sufficient to induce hypertrophy and proliferation, resulting in excessive granuloma formation in vivo.
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