Publications by authors named "Florentina Teoderascu"
Article Synopsis
- Degenerative cervical myelopathy (DCM) leads to variable neurological decline, especially affecting upper limb function, but current assessments like the mJOA score don’t effectively capture subtle changes.
- The study aimed to evaluate arm and hand function in DCM patients and to create the GRASSP-M tool, which objectively measures upper limb impairment.
- Findings revealed significant declines in strength, sensation, and manual dexterity with DCM severity, with GRASSP-M demonstrating high reliability and validity, indicating it can better assess functional impairment than subjective measures.
Despite clear evidence of immunogenicity, cancer vaccines only provide a modest clinical benefit. To evaluate the mechanisms that limit tumor regression following vaccination, we have investigated the weak efficacy of a highly immunogenic experimental vaccine using a murine melanoma model. We discovered that the tumor adapts rapidly to the immune attack instigated by tumor-specific CD8+ T cells in the first few days following vaccination, resulting in the upregulation of a complex set of biological networks, including multiple immunosuppressive processes.
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