AI-guided identification of risk variants for adrenocortical tumours in p.R337H carrier children: a genetic association study.

Background: Adrenocortical tumours (ACT) in children are part of the Li-Fraumeni cancer spectrum and are frequently associated with a germline pathogenic variant. p.R337H is highly prevalent in the south and southeast of Brazil and predisposes to ACT with low penetrance.

Visual Quality of 3D Meshes With Diffuse Colors in Virtual Reality: Subjective and Objective Evaluation.

Surface meshes associated with diffuse texture or color attributes are becoming popular multimedia contents. They provide a high degree of realism and allow six degrees of freedom (6DoF) interactions in immersive virtual reality environments. Just like other types of multimedia, 3D meshes are subject to a wide range of processing, e.

Probing the functional impact of sub-retinal prosthesis.

Retinal prostheses are promising tools for recovering visual functions in blind patients but, unfortunately, with still poor gains in visual acuity. Improving their resolution is thus a key challenge that warrants understanding its origin through appropriate animal models. Here, we provide a systematic comparison between visual and prosthetic activations of the rat primary visual cortex (V1).

Just Noticeable Distortion Profile for Flat-Shaded 3D Mesh Surfaces.

It is common that a 3D mesh undergoes some lossy operations (e.g., compression, watermarking and transmission through noisy channels), which can introduce geometric distortions as a change in vertex position.

Post-implantation impedance spectroscopy of subretinal micro-electrode arrays, OCT imaging and numerical simulation: towards a more precise neuroprosthesis monitoring tool.

Objective: Previous studies have shown that single-frequency impedance measurements could provide useful information about the distance between the neuroprosthesis and the retina. This work investigates the use of impedance spectroscopy in monitoring subretinal implantations of flexible micro-electrode arrays and focuses on determining what is governing impedance profiles.

Approach: In this study, we use impedance spectroscopy together with optical coherence tomography imaging and numerical simulation to quantitatively evaluate the constituent elements of measured impedance.