Publications by authors named "Florent Bertrand"
Article Synopsis
- - Macrophages play a crucial role in HIV-1 infection and serve as significant viral reservoirs, particularly in various tissues where they are not easily infected by free virus.
- - The study reveals that HIV-1 can efficiently infect macrophages through cell fusion with infected CD4+ T cells, highlighting a critical method of viral transmission in vivo.
- - This fusion process varies based on the polarization state of the macrophages and is regulated by a specific adhesion structure and the CD81 tetraspanin, which influences cellular contractility during the infection.
HIV-1 infection is frequently associated with low bone density, which can progress to osteoporosis leading to a high risk of fractures. Only a few mechanisms have been proposed to explain the enhanced osteolysis in the context of HIV-1 infection. As macrophages are involved in bone homeostasis and are critical host cells for HIV-1, we asked whether HIV-1-infected macrophages could participate in bone degradation.
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