Publications by authors named "Florent Arregle"
Background: Transcatheter aortic valve replacement-related infective endocarditis (TAVR-IE) is associated with a poor prognosis. TAVR-IE diagnosis is challenging, and benefits of the most recent classifications (ESC-2015, ISCVID-2023 and ESC-2023) have not been compared with the conventional Duke criteria on this population.
Objectives: The primary objective was to compare the diagnostic value of the Duke, ESC-2015, ISCVID-2023, and ESC-2023 criteria for the diagnosis of TAVR-IE.
Intra-pericardial rupture of a caseous calcified mass of the mitral annulus.
J Cardiovasc Comput Tomogr
October 2023
TREATMENT OF INFECTIVE ENDOCARDITIS. Patients with infective endocarditis (IE) are taken care for by multidisciplinary teams. The treatment consists of antibiotic therapy initiated early, adapted to the responsible germ and prolonged, associated with surgical treatment when there is an indication for surgery.
View Article and Find Full Text PDFBackground: Aortic valve infective endocarditis may be complicated by high-degree atrioventricular block in up to 10-20% of cases.
Aim: To assess high-degree atrioventricular block occurrence, contributing factors, prognosis and evolution in patients referred for aortic infective endocarditis.
Methods: Two hundred and five patients referred for aortic valve infective endocarditis between January 2018 and March 2021 were included in this study.
Article Synopsis
- * Researchers compared two groups of patients—one from the pandemic period and one from the previous year—looking at their clinical outcomes, treatments, and overall management.
- * The findings indicated that the pandemic did not significantly affect the treatment and mortality rates of IE patients, though there was an increase in intravenous drug-related cases, highlighting a potential psychosocial impact of the pandemic.
Background: Hepatic artery aneurysms (HAAs), albeit rare in infective endocarditis (IE), are associated with a life-threatening morbidity.
Methods: Retrospective review of 10 HAA-IE patients based on a total of 623 IE patients managed in 2 institutions (2008-2020) versus 35 literature cases.
Results: In our patient population, HAAs (10 males, mean age 48) were incidentally found during IE workup.
Importance: It is suggested that patients with Cutibacterium acnes endocarditis often present without fever or abnormal inflammatory markers. However, no study has yet confirmed this statement.
Objective: To assess the clinical characteristics and outcomes of patients with C acnes endocarditis.
Multimodality imaging in marantic endocarditis associated with cancer: a multicentric cohort study.
Eur Heart J Cardiovasc Imaging
November 2023
Aims: We aimed to assess the role of multimodality imaging (MMI) in the diagnosis of marantic endocarditis (ME) associated with cancers and to describe the clinical characteristics, management, and outcome of these patients.
Methods And Results: In a retrospective multicentric study including four tertiary centres for the treatment of endocarditis in France and Belgium, patients with a diagnosis of ME were included. Demographic, MMI [echocardiography, computed tomography (CT), and 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)], and management data were collected.
Background: The influence of different bicuspid aortic valve (BAV) morphology in the clinical course of infective endocarditis (IE) has not yet been investigated. This study aimed to describe the clinical and echocardiographic features of IE in patients with BAV (BAVIE) according to valve morphology.
Methods: Patients with definite BAVIE prospectively enrolled in 4 high-volume referral centers from 2000 to 2019 were evaluated and divided into 2 groups according to the echocardiographic definition of fused BAV morphology: right-left coronary (RL type) and right noncoronary or left noncoronary (non-RL type) cusp fusion.
Influence of the healthcare pathway on the outcome of patients with infective endocarditis.
Eur Heart J Acute Cardiovasc Care
September 2022
Article Synopsis
- The study investigates the prognosis of patients with infective endocarditis (IE) based on their healthcare pathway and the application of ESC guidelines in their treatment.
- Conducted in 22 hospitals in South-East France, the research involved 342 patients divided into three groups: those treated entirely in referral centers, those initially treated in non-referral centers then referred, and those entirely treated in non-referral centers.
- Results showed a one-year mortality rate of 26%, with significantly higher mortality (37%) for patients treated solely in non-referral centers compared to those in referral and transferred centers, indicating that healthcare pathway significantly impacts patient outcomes.*
Whipple's disease (WD) is a chronic multisystemic infection caused by . If this bacterium presents an intracellular localization, associated with rare diseases and without pathognomonic signs, it is often subject to a misunderstanding of its physiopathology, often a misdiagnosis or simply an oversight. Here, we report the case of a patient treated for presumed rheumatoid arthritis.
View Article and Find Full Text PDFBackground: In native mitral valve infective endocarditis (NMIE), the respective values of mitral valve repair (MVRep) and replacement (MVR) are still debated.
Aim: To compare MVRep and MVR in a large prospective matched cohort.
Methods: Between 2010 and 2017, all consecutive patients operated on for NMIE in our centre were included prospectively.
Background: Infective endocarditis (IE) is associated with a high mortality rate, related in part to neurological complications. Studies suggest that valvular surgery should be performed early when indicated, but is often delayed by the presence of neurological complications.
Aim: To assess the effect of delaying surgery in patients with IE and neurological complications and to identify factors predictive of death.
Article Synopsis
- F-FDG PET/CT is now included in the ESC 2015 guidelines for diagnosing infective endocarditis, but its effectiveness in native valve endocarditis (NVE) is not fully understood.
- A study involving 75 patients identified that while F-FDG PET/CT had low sensitivity (17.5%) for diagnosing NVE, it maintained high specificity (100%) and was effective for detecting embolic events.
- The research also revealed a new diagnostic feature of diffuse splenic uptake seen in over half of the patients with NVE, suggesting its potential utility in clinical practice.
Background: Most cases of left-sided native valve infective endocarditis (IE) involve a single valve and little is known concerning IE that simultaneously affects the aortic and mitral valves.
Methods: We aimed to determine the characteristics, identify the prognostic factors, and define the effect of early surgery for patients with left-sided native bivalvular IE. This analysis included 1340 consecutive patients who presented with definite acute left-sided native valve IE in a 2-centre cohort study.
Article Synopsis
- The study aimed to evaluate the effectiveness of F-FDG-PET/CT as part of the ESC criteria for diagnosing prosthetic valve infective endocarditis (PVE), while also comparing it to traditional echocardiography.
- Researchers analyzed data from 175 patients suspected of having PVE, ultimately focusing on 115 patients whose F-FDG-PET/CT results were interpretable.
- Results showed that while F-FDG-PET/CT increased the sensitivity of the ESC criteria compared to the Duke criteria, it also decreased specificity, and the presence of diffuse splenic uptake was notable in a significant portion of patients with definitive PVE.
Objective: The primary objective was to assess the characteristics and prognosis of pyogenic spondylodiscitis (PS) in patients with infective endocarditis (IE). The secondary objectives were to assess the factors associated with occurrence of PS.
Methods: Prospective case-control bi-centre study of 1755 patients with definite IE with (n=150) or without (n=1605) PS.
Western Immunoblotting for the Diagnosis of and Infective Endocarditis.
Front Cell Infect Microbiol
June 2020
Blood culture-negative endocarditis (BCNE) remains a diagnostic challenge. In our center, despite a systematic and exhaustive microbiological diagnostics strategy, 22% of patients with BCNE remain without an identified etiology. In an effort to determine the relevance of using Western blot (WB) for the etiological diagnosis of BCNE in patients with early antibiotic use, we developed specific assays for the major infective endocarditis (IE) causative agents, namely, , and .
View Article and Find Full Text PDFBackground: F-fluorodeoxyglucose positron emission tomography/computed tomography (F-FDG PET/CT) is commonly used for the diagnosis of infective endocarditis (IE), but its prognostic value remains unknown.
Objectives: This study sought to assess the prognostic value of F-FDG PET/CT in prosthetic valve endocarditis (PVE) and native valve endocarditis (NVE).
Methods: This study prospectively included 173 consecutive patients (109 PVE and 64 NVE) with definite left-sided IE who had an F-FDG PET/CT and were followed-up for 1 year.
Article Synopsis
- The study aimed to assess the effectiveness and safety of a new treatment regimen combining intravenous trimethoprim-sulfamethoxazole and clindamycin (T&C) for Staphylococcus aureus endocarditis compared to traditional treatments.
- It involved 341 patients, with 170 receiving standard treatment before 2012 and 171 receiving the T&C protocol after implementation in 2012.
- Results showed that the T&C group had lower global, in-hospital, and 30-day mortality rates and a significantly shorter average hospital stay compared to the control group.