Publications by authors named "Florence Schlink"
J Extracell Vesicles
August 2020
Article Synopsis
- Extracellular vesicles (EVs) facilitate communication between cells and are promising for regenerative therapy, particularly after ischaemic stroke, which damages brain tissue due to loss of oxygen and glucose.
- This study explores the characteristics of EVs in mice, revealing that under normal conditions, microglia produce most small extracellular vesicles (sEVs), while after a stroke, astrocytes become the main source.
- The research shows that EVs are enriched with prion protein (PrP), particularly a truncated fragment (PrP-C1), and that EVs lacking PrP are absorbed more efficiently by neurons and glial cells, suggesting the role of these proteins in how sEVs are taken up after a stroke
