Publications by authors named "Florence Millette"
Article Synopsis
- Multiple sclerosis (MS) is an autoimmune disease that damages myelin in the central nervous system, leading to injury of brain and spinal cord cells due to immune cell infiltration, particularly by pro-inflammatory Th17 cells.
- The study investigated how these Th17 cells interact with oligodendrocytes (the myelin-producing cells) through specific adhesion molecules, finding that the presence of certain molecules like ALCAM helps these cells adhere, which can lead to cell death.
- Results showed that in the presence of inflammatory cytokines or activated T cells, the expression of MCAM decreased, offering protective insights that targeting ALCAM could reduce harmful interactions between Th17 cells and oligodendrocytes, potentially leading to new therapeutic strategies for
Article Synopsis
- The study examines the role of inflammation in drug-resistant epilepsy (DRE) and evaluates how two new anti-epileptic drugs (AEDs), brivaracetam and lacosamide, affect immune cell activation.
- Research shows that both AEDs do not negatively impact the survival or activation of immune cells at lower doses, but higher doses reduce CD8 T cell proliferation and certain markers.
- Although these AEDs do not delay the onset of experimental autoimmune encephalomyelitis (EAE), they improve the disease's clinical course, suggesting they may help reduce neuroaxonal damage in DRE.
