Publications by authors named "Florence Jacomet"
Background: Polyclonal hypergammaglobulinaemia (PH) represents a classic diagnosis problem in internal medicine. However, there is no consensus threshold for PH. The aim of this study was to define a threshold for PH.
View Article and Find Full Text PDFArticle Synopsis
- Polyclonal hypergammaglobulinaemia (PH) is a common diagnostic challenge in internal medicine, and this study aimed to establish a consensus threshold for PH based on serum protein electrophoresis (SPE) data from 2016.
- The researchers analyzed data from over 20,700 SPEs across three hospitals and found that the 95th percentile threshold for PH was 18.9 g/L, noting variations based on geographical regions.
- The study concludes that while the 19 g/L threshold may be significant, its biological nature requires validation through future prospective studies to determine its clinical relevance.
Article Synopsis
- The study focuses on the immune mechanisms behind treatment-free remission (TFR) in chronic myeloid leukemia (CML), highlighting the lack of defined correlations with CD8(+) T-cell types.
- Researchers identified a new subset of CD8(+) T-cells called innate CD8(+) T-cells in CML patients who enjoyed TFR for over two years, showing a significant increase in their functionality compared to control and treated patients.
- The findings suggest a positive relationship between the levels of innate CD8(+) T-cells and natural killer cells, indicating a potential new biomarker profile for successful TFR in CML patients.
Unconventional T cells are defined by their capacity to respond to signals other than the well-known complex of peptides and major histocompatibility complex proteins. Among the burgeoning family of unconventional T cells, innate-like CD8(+) T cells in the mouse were discovered in the early 2000s. This subset of CD8(+) T cells bears a memory phenotype without having encountered a foreign antigen and can respond to innate-like IL-12 + IL-18 stimulation.
View Article and Find Full Text PDFArticle Synopsis
- Researchers discovered a new type of NK-like CD8(+) T cells in humans, which are potent in fighting off infections and tumors, similar to invariant natural killer T (iNKT) cells.
- In patients with chronic myeloid leukemia (CML), these innate CD8(+) T cells were found to be significantly reduced and functionally impaired, showing a loss of their natural ability to fight disease.
- Patients achieving complete remission through treatment showed some recovery in the number and function of these innate CD8(+) T cells, highlighting a potential link between these cells and the effectiveness of iNKT cells in immune responses.
Article Synopsis
- Researchers have identified a new subset of CD8(+) T cells in humans that share characteristics with a type found in mice, showing features like high Eomes expression and rapid IFN-γ production without prior exposure to antigens.
- These KIR/NKG2A(+) CD8(+) T cells demonstrate potent antigen-independent cytotoxic activity and possess a terminally differentiated effector memory phenotype.
- The findings suggest that these T cells may represent a distinct "innate/memory-like" functional group in humans, which was also observed in cord blood, indicating their development doesn't rely on prior antigen exposure.
Although it is generally acknowledged that cytokines regulate normal hematopoiesis in an autocrine/paracrine fashion, their possible role in chronic myelogenous leukemia (CML) and resistance to imatinib mesylate treatment remain poorly investigated. Here, we report that CD34(+) progenitors from patients with CML at diagnosis are selectively targeted by the cytokine/alarmin interleukin (IL)-33. Indeed, CML CD34(+) progenitors upregulate their cell surface expression of the IL-33-specific receptor chain ST2, proliferate and produce cytokines in response to IL-33, conversely to CD34(+) cells from healthy individuals.
View Article and Find Full Text PDFChronic myeloid leukemia (CML) is a clonal hematopoietic stem-cell malignancy characterized by the presence of the chimeric BCR-ABL oncoprotein with deregulated tyrosine-kinase (TK) activity. Although conventional T cells are acknowledged as important players in the control of CML, a possible modification of invariant NKT (iNKT) cells, known for their antitumoral activity, has not been established as yet. Here, we showed that the expression of perforin, CD95L, and promyelocytic leukemia zinc finger, a transcription factor required for maintenance of iNKT cell functions, was reduced or suppressed in CML patients at diagnosis, as compared with healthy individuals.
View Article and Find Full Text PDFArticle Synopsis
- Researchers explored using autologous cryopreserved mononuclear cells (MNCs) for extracorporeal photochemotherapy (ECP), which can improve treatment accessibility and reduce the frequency of procedures.
- Three patients with different conditions (dermatomyositis, localized scleroderma, and graft-versus-host disease) underwent cryo-ECP, which involved using both fresh and frozen cell fractions to minimize apheresis sessions.
- The results showed that cryo-ECP was safe and effective, suggesting it could make ECP treatments more convenient and expand its use for various diseases.
Article Synopsis
- The study focused on improving the detection of anti-dsDNA antibodies, crucial for diagnosing systemic lupus erythematosus, by comparing two testing techniques: ELISA and CLIFT.
- Researchers analyzed 1,729 tests over 18 months, using CLIFT for cases that didn't match ELISA results or based on clinical data, leading to 96 CLIFT tests conducted.
- Findings showed that using both techniques increased sensitivity, identifying additional lupus cases and revealing potential false positives from ELISA, validating the dual approach for cost-effective lab use.