Publications by authors named "Florence Canoui Poitrine"
Hypothesis: To evaluate how comorbidities affect mortality benefits of lung cancer screening (LCS) with low-dose computed-tomography (LDCT).
Methods: We developed a comorbidity index (PLCO-ci) using LCS-eligible participants' data from the Prostate Lung Colorectal and Ovarian (PLCO) trial (training set) and the National Lung Screening Trial (NLST) (validation set). PLCO-ci predicts 5-year non-lung cancer (LC) mortality using a regularized Cox model; with performance evaluated by the area under the ROC curve (ROC).
Background: Immune ageing complicates cancer treatment in older individuals. While immunotherapy targeting the PD-1/PD-L1 pathway can reinvigorate T cells, these cells tend to become senescent with age. This study investigates different CD8 T cell subsets usually associated with senescence, in cancer patients over 70 years old who are undergoing anti-PD-1/PD-L1 immunotherapy, and examines the relationship between these senescent cells and prior chemotherapy exposure.
View Article and Find Full Text PDFIntroduction: In the past, certain oncological therapies were not offered to frail older patients. However, the advancement of geriatric oncology, tailored chemotherapy regimens, the introduction of new treatments, and the optimization of supportive care have contributed to enhancing the therapeutic margin. We aimed to evaluate the benefit of systemic treatment among older adults by assessing the three-month survival of older frail patients with metastatic cancer.
View Article and Find Full Text PDFBackground: The longitudinal hospital care experiences of older adults with cancer, from the treatment decision-making process until their end of life, remain unexplored. We examined the hospital care trajectories of these patients and identified associated clinical determinants.
Materials And Methods: We linked the ELCAPA multicenter cohort study (patients aged ≥70 with a solid tumor and having been referred for a geriatric assessment between 2012 and 2019) and the Greater Paris University Hospitals' clinical data warehouse.
Article Synopsis
- The study assesses the safety and efficacy of the anti-CD38 monoclonal antibody daratumumab for kidney transplant candidates with high panel reactive antibodies.
- In the trial, 23 patients were involved across two phases, with notable mild infusion-related adverse events but no serious complications.
- Results showed significant, temporary reductions in anti-HLA antibodies at 3 months, but most immune markers returned to baseline levels after 12 months, indicating less than 40% of patients had a lasting positive response.
Article Synopsis
- - The study evaluates the Hospital Frailty Risk Score (HFRS) and its effectiveness in predicting outcomes like care consumption, frailty issues, and mortality among older cancer patients, compared to the Geriatric 8 (G8) screening tool.
- - Data was collected from 587 patients aged 70 and older with solid tumors in a hospital setting, focusing on various health aspects including cognitive function, nutrition, and mobility, using regression analyses to draw associations between HFRS, G8, and various health outcomes.
- - Results indicated that while HFRS was linked to several health impairments and short-term care metrics, it failed to effectively identify issues related to polypharmacy, nutrition, and mood, showcasing
Article Synopsis
- The LUMASCAN study focused on evaluating the acceptability and feasibility of screening for lung cancer, chronic obstructive pulmonary disease (COPD), and cardiovascular diseases (CVD) in a community setting using low-dose CT scans.
- The study enrolled 302 participants, primarily active smokers, with notable participation rates of 99% at inclusion, but dropping to 79% by two years after initial enrollment.
- Results showed that 4% had lung cancer, 27% had unknown obstructive lung disease, and 43.4% had significant coronary artery calcifications, confirming the effectiveness of combined screening for these diseases.
Article Synopsis
- Many new cancer cases happen in older people, who often suffer from various problems that can make their treatment harder.
- The study looked at how different types of suffering, like physical pain and emotional stress, affect cancer treatment and how long older patients might live.
- Results showed that physical suffering impacts how well cancer can be treated and how long patients survive, and that emotional and family issues also play a role in their health and care needs.
Background: Health policymakers have tried to improve the care pathway for cancer patients by improving collaboration between participating healthcare professionals by involving the general practitioner (GP).
Objective(s): To explore how patients, GPs, oncologists and nurses interacted and how they perceived, in their practice, professional roles, collaboration, and cancer care pathways.
Methods: Between January 2018 and December 2021, we conducted a qualitative study that combined phenomenology and a general inductive analysis, based on semi-structured interviews with cancer patients and their GPs, oncologists, and nurses in France.
Article Synopsis
- The study focuses on transthyretin cardiac amyloidosis (ATTR-CM) as a significant cause of heart failure in older patients, analyzing how age and amyloidosis subtype affect patient outcomes.
- It included 943 patients, revealing that geriatric patients (≥75 years) had worse health outcomes and lower 3-year survival rates (55%) compared to non-geriatric patients (<75 years) who had a survival rate of 76%.
- Key mortality predictors differed by age group, with geriatric patients relying on alkaline phosphatase and troponin T levels, while non-geriatric patients linked outcomes to NT-proBNP and glomerular filtration rates; a new 3-stage prognostic
Immune thrombocytopenia newly diagnosed during pregnancy: Outcome for mothers and neonates and comparison with chronic immune thrombocytopenia during pregnancy.
Am J Hematol
October 2024
Background: Currently available predictive models for chemotherapy-related toxicity are not sufficiently discriminative in older patients with cancer and do not consider moderate toxicities. The purpose of this study was to identify factors associated with moderate and severe chemotherapy toxicities in older patients with cancer.
Materials And Methods: Patients aged 70+ recruited in the prospective ELCAPA cohort were analyzed.
Background: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient's medical management (outpa-tient care, standard hospital admission, and ICU admission).
Methods: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing.
Objective: To assess the prognostic value of neurocognitive disorder (NCD) for 12 month-overall mortality in patients aged 70 or more with a solid cancer.
Design: prospective, observational, multicenter cohort.
Setting And Participants: We analyzed data from the ELCAPA longitudinal multicenter observational cohort of patients aged 70 or over, referred for a geriatric assessment (GA) before a new cancer treatment modality between January 31st, 2007, and December 29th, 2017.
Objectives: The primary objective of the present study was to evaluate and compare the ability of eight nutrition-related tools to predict 1-year mortality in older patients with cancer.
Design, Setting And Participants: We studied older patients with cancer from the ELCAPA cohort and who had been referred for a geriatric assessment at one of 14 participating geriatric oncology clinics in the greater Paris area of France between 2007 and 2018.
Measurements: The studied nutrition-related tools/markers were the body mass index (BMI), weight loss (WL) in the previous 6 months, the Mini Nutritional Assessment, the Geriatric Nutritional Risk Index (GNRI), the Prognostic Nutritional Index, the Glasgow Prognostic Score (GPS), the modified GPS, and the C-reactive protein/albumin ratio.
Article Synopsis
- The study examines the entire pathway of older adults’ participation in cancer clinical trials, identifying rates of non-invitation and refusal.
- It highlights sociocultural factors, such as social isolation and family dynamics, as major reasons for lower participation rates among older patients.
- The findings indicate that improving inclusion in clinical trials should focus on the interaction between healthcare professionals and patients, rather than solely on the patients themselves.
Article Synopsis
- Head and neck cancer significantly affects the quality of life (QoL) of older patients, with this study evaluating the impact of geriatric-assessment (GA)-based interventions on QoL over two years.
- The study involved 475 patients aged 65 and older, comparing those who received a GA-driven intervention to those receiving standard care, using specific QoL questionnaires for measurement.
- Results showed improvements in QoL scores overall, but no major differences between the intervention and control groups; most patients in the intervention group did not complete the full treatment, highlighting the need for better healthcare models tailored to patients' needs.
Background: Hypercapnia worsens lung vascular dysfunction during acute respiratory distress syndrome (ARDS). We tested whether an extracorporeal carbon dioxide removal (ECCOR) device based on a renal replacement therapy platform (Prismalung®) may reduce PaCO and alleviate lung vascular dysfunction in ARDS patients with refractory hypercapnia.
Methods: We planned to prospectively include 20 patients with moderate-to-severe ARDS, pulmonary vascular dysfunction on echocardiography, and PaCO ≥ 48 mmHg despite instrumental dead space reduction and the increase in respiratory rate.
National cross-sectional survey on psychological impact on French nursing homes of the first lockdown during the COVID-19 pandemic as observed by psychologists, psychomotor, and occupational therapists.
Front Public Health
January 2024
Objectives: The main objective was to explore the psychological impact of the French lockdown during the first wave of the COVID-19 pandemic on nursing home residents, their relatives, and healthcare teams, as observed by mental health professionals.
Design: A national online cross-sectional survey was conducted from May 11 to June 9, 2020.
Setting And Participants: Respondents were psychologists, psychomotor therapists, and occupational therapists (mental health professionals).
The ecological sustainability of the operating room (OR) is a matter of recent interest. The present systematic review aimed to review the current literature assessing the carbon footprint of surgical procedures in different surgical fields. Following to the PRISMA statement checklist, three databases (MEDLINE, EMBASE, Cochrane Library) were searched by independent reviewers, who screened records on title and abstract first, and then on the full text.
View Article and Find Full Text PDFBackground Estimating glomerular filtration rate (GFR) from serum creatinine can be inaccurate, and current procedures for measuring GFR are time-consuming and cumbersome. Purpose To develop a method for measuring GFR based on iomeprol clearance assessed at CT urography in kidney donor candidates and compare this with iohexol clearance (reference standard for measuring GFR). Materials and Methods This cross-sectional retrospective study included data from kidney donor candidates who underwent both iohexol clearance and CT urography between July 2016 and October 2022.
View Article and Find Full Text PDFBackground: In older patients with cancer, comorbidities compete with cancer for cause of death. The objectives were to evaluate cancer mortality and factors associated, according to metastatic status.
Methods: Between 2007 and 2014, patients with cancer aged ≥70 referred for pre-therapeutic geriatric assessment (GA) were included through the ELCAPA prospective cohort study.
Individual and contextual risk factors for mortality in nursing home residents during the first wave of COVID-19 in France: a multilevel analysis of a nationwide cohort study.
Age Ageing
August 2023
Background: Mortality amongst nursing home (NH) residents increased by 43% during the first wave of coronavirus disease 2019 (COVID-19). We estimated the 'contextual effect' on mortality, tried to explain it by NH characteristics and identified resident- and NH-level risk factors for mortality.
Methods: The contextual effect was measured for two cohorts of NH residents managed by the general scheme in metropolitan France (RESIDESMS data from 03/01/2020 to 05/31/2020 and 03/01/2019 to 05/31/2019) by the intraclass correlation coefficient (ICC) estimated from mixed-effects logistic regression.
Objective: The primary objective was to describe the occupations people engaged in more frequently during lockdown than before the coronavirus disease 2019 pandemic as a function of generation. The secondary objectives were to (i) describe the levels of importance, performance, and satisfaction for these occupations and (ii) identify factors affecting the levels of importance, performance, and satisfaction.
Method: We conducted an online, cross-sectional survey of young adults (YAs, aged 18-39), middle-aged adults (MAs, aged 40-59), and older adults (OAs, aged 60 or over).