Publications by authors named "Florence Benech"
Objective: The objective of these studies was to investigate whether a skincare product containing Ambophenol, Neurosensine, and La Roche-Posay thermal spring water formulated in a highly protective packaging can have an impact in the management of rosacea-prone skin subjects.
Methods: Several studies were performed to evaluate the efficacy of this product in the management of rosacea prone skin, as either monotherapy or adjunctive therapy or to maintain the efficacy of a Metronidazole treatment. The first study was performed on 37 women aged 18-45 with added stage 2 erythro-couperosis, who applied test formula as monotherapy twice a day for 4 weeks.
Introduction: A monocentre double-blind two parallel group clinical study was conducted to assess whether a new skincare regimen containing retinol, adenosine and hyaluronic acid, applied after the injection of botulinum toxin A to the glabellar area, provided a beneficial effect.
Material And Methods: Standardised photographs acquired using LifeViz cameras and zoomed pictures of the glabella and of the crow's feet areas were analysed with automatic well-defined procedures. Perceived efficacy and tolerance were also analysed by comparison between the two groups.
Article Synopsis
- - The study aimed to assess the melanogenic activity of human hair follicles using [14C]-2-thiouracil, which integrates into melanin.
- - Results showed that [14C]-2-TU was mainly incorporated in pigmented hair follicles, particularly around the dermal papilla and within the hair fiber, with increased incorporation when treated with forskolin, linked to elevated tyrosinase levels.
- - In contrast, the competitive inhibitor kojic acid led to a significant decrease in [14C]-2-TU incorporation, while the MC1-R agonist alpha-MSH did not result in notable changes, highlighting the potential of this model for studying hair pigmentation regulators.
NAD(+) dependent 15-hydroxyprostaglandin dehydrogenate (15-PGDH) catalyses oxidation of 15(S)-hydroxyl group of prostaglandins and as a result inactivates their physiological potential. Positive effects of prostaglandins or prostaglandin analogues were reported on terminal hair, vellus hair or eyelash growth and a complex prostaglandin network was recently described in human hair follicle. In the present study, we showed that 15-PGDH was expressed in human hair follicle mainly in melanocytes and keratinocytes, which brought us to consider this enzyme as a possible target to sustain local prostaglandin production.
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