Meta-Analysis of Polymorphisms with Air Pollution on the Risk of Ischemic Heart Disease Worldwide.

The purpose of this updated meta-analysis was to investigate the effect of nitric oxide synthase-3 ( G894T polymorphisms, air pollution and their interaction on ischemic heart disease (IHD) risk across populations worldwide. Recursive partition trees, nonlinear association curve fit and geographic information system maps were incorporated to verify results of conventional pooled analyses for sources of heterogeneity. Results from 61 studies (16,219 cases, 12,222 controls) revealed a significant increased relative risk (RR) of IHD associated with 894 polymorphisms TT (RR = 1.