Publications by authors named "Flora de Andrade Gandolfi"
Article Synopsis
- Chikungunya virus (CHIKV) has been spreading variably across Brazil, and its impact in São José do Rio Preto (SJdRP) is studied to understand the low incidence of reported cases, despite the potential for underdiagnosis due to overlapping symptoms with other viruses like dengue.
- A study involving 341 asymptomatic individuals over four years showed an increase in anti-CHIKV IgG seroconversion from 0.35% to 2.3%, and 4.4% of dengue-suspected individuals tested positive for anti-CHIKV IgM during a 2019 outbreak.
- Genomic analysis confirmed the presence of the ECSA genotype of CHIKV in SJd
The disease burden of yellow fever virus infection (YFV) is quite high in the tropics where vaccination coverage is low. To date, vaccination is the most effective control strategy to mitigate and eliminate the burden of YF disease. The licensed YF vaccines are safe and effective and serious adverse events are rare.
View Article and Find Full Text PDFMeasles is a highly contagious acute febrile disease responsible for sporadic but explosive outbreaks worldwide. Although it was considered eliminated from the Americas, the disease reemerged in 2017. This reemergence was linked to reduced immunization rates.
View Article and Find Full Text PDFArticle Synopsis
- SARS-CoV-2 uses the ACE2 receptor to infect various human tissues, with higher levels of ACE2 observed in patients with comorbidities linked to severe COVID-19.
- Patients with Barrett's esophagus (BE) exhibit increased ACE2 expression in BE tissues, potentially due to the lower pH associated with this condition.
- The study indicates that lower pH increases ACE2 expression and viral load in human monocytes and that prior use of proton pump inhibitors may significantly elevate the risk of death from COVID-19.