Publications by authors named "Flora T Mambe"
Article Synopsis
- The study investigated the antibacterial properties of methanol extracts from the leaves (APL) and bark (APB) of a specific plant against multidrug-resistant Gram-negative bacteria.
- Compounds were isolated from the leaf extract, leading to promising results, with certain isolated compounds showing high effectiveness against various bacterial strains.
- The addition of an efflux pump inhibitor (EPI) significantly enhanced the antibacterial activity of the extracts and compounds, showing potential for use alongside antibiotics to treat bacterial infections.
Background: Cancer chemotherapy is still hampered by clinical failures due to multi-drug resistance (MDR) of tumor cells. In the present study, we have investigated the cytotoxicity of 20 methanol extracts from 10 medicinal plants against the sensitive leukemia CCRF-CEM cells. The most cytotoxic extracts were then further tested on a panel of 8 human cancer cell lines, including various MDR phenotypes.
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