Evaluating the hepatoprotective, ameliorative and antioxidant potentials of the crude aqueous leafy extracts of plant against acute paracetamol-induced hepatotoxicity in a mouse model.

Background: Drug-induced hepatotoxicity is a major public health issue of concern. It significantly affects the development of new pharmaceutical drugs and has led to the withdrawal of many promising pharmaceutical drugs from the pharmaceutical market.

Aim: The aim of this study was to evaluate the hepatoprotective, ameliorative and antioxidant effects of the crude aqueous leafy extract of plant and its different separating medium fractions against acute acetaminophen (paracetamol)-induced hepatotoxicity in a mouse model.

Evaluation of the toxicity potential of acute and sub-acute exposure to the aqueous root extract of Aristolochia ringens Vahl. (Aristolochiaceae).

Ethnopharmacological Relevance: Aristolochia ringens Vahl. (Aristolochiaceae) is used traditionally in Nigeria for managing a number of ailments including gastrointestinal disturbances, rheumatoid arthritis, pile, insomnia, oedema, and snake bite venom. Some studies in our laboratory have demonstrated a scientific justification for some of such uses.

Alterations of haemodynamic parameters in spontaneously hypertensive rats by A Vahl. (Aristolochiaceae).

Vahl. (Aristolochiaceae (AR) is used traditionally in Nigeria for the management of various disorders including oedema. Preliminary investigation revealed its modulatory effect on the cardiovascular system.

Toxicological evaluation of the aqueous whole plant extract of Aerva lanata (l.) Juss. ex Schult (Amaranthaceae).

Ethnopharmacological Relevance: Aerva lanata (L.) of the family Amaranthaceae is a Nigerian medicinal plant used traditionally for the management of lithiasis, headache, renal disorder, haematemesis, bronchitis, nasal bleeding, cough, scorpion stings, fractures and spermatorrhoea. Studies that show the pharmacological basis for some of such uses have been reported.

Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae).

Cancer is a leading cause of death worldwide and sustained focus is on the discovery and development of newer and better tolerated anticancer drugs especially from plants. The sulforhodamine B (SRB) in vitro cytotoxicity assay, sarcoma-180 (S-180) ascites and solid tumor, and L1210 lymphoid leukemia in vivo models were used to investigate the anticancer activity of root extracts of Aristolochia ringens Vahl. (Aristolochiaceae; mǎ dōu líng).

Effects of Telfairia occidentalis (fluted pumpkin; Cucurbitaceae) in mouse models of convulsion, muscle relaxation, and depression.

Telfairia occidentalis (Cucurbitaceae) is a leafy vegetable used in soup and folk medicine in southern Nigeria. Ethnobotanical survey revealed that preparations of the plant are used in the treatment of central nervous system-related disorders including convulsion. This study was conducted to investigate the effect of the hydroethanolic leaf extract of T.

Analgesic and anti-inflammatory activities of the aqueous stem and leaf extract of Asystasia gangetica (Linn) T. Anderson.

Background: Asystasia gangetica (Linn) T. Anderson [family Acanthaceae] is used commonly in the sub-tropics and tropics for the management of inflammatory and algesic conditions.

Objective: The study was done to evaluate the analgesic and inflammatory activity of the aqueous stem and leaf extract of Asystasia gangetica.