Publications by authors named "Flor Munoz-Rivas"
Article Synopsis
- Pregnant women and their babies face increased risks during epidemics, necessitating a coordinated research response to ensure they receive adequate disease prevention and care, similar to the general population.* -
- Researchers conducted literature searches and expert consultations from 2015 to 2022, identifying 94 relevant research initiatives, but found major gaps in infrastructure, governance, and funding that hinder effective responses during health crises.* -
- The study suggests that enhancing collaboration among international and regional networks could improve maternal and perinatal research readiness and response, ultimately leading to better access to care and countermeasures for this vulnerable group during future outbreaks.*
Trends in Disease Severity Among Critically Ill Children With Severe Acute Respiratory Syndrome Coronavirus 2: A Retrospective Multicenter Cohort Study in the United States.
Pediatr Crit Care Med
January 2023
Article Synopsis
- This study assessed trends in pediatric critical illness due to SARS-CoV-2 during the COVID-19 pandemic, focusing on differences between the Omicron wave in January 2022 and the original outbreak in March 2020.
- It found that while PICU admissions were seven times higher during the Omicron period, the need for endotracheal intubation was either reduced or unchanged, suggesting that younger patients may have been affected differently.
- The study included 267 patients, highlighting the importance of ongoing research into the varying impacts of COVID-19 on children throughout different phases of the pandemic.
We determined optimal vancomycin starting dose regimens in infants ≤180 days of age to achieve the highest probability of target attainment with an area under the concentration-time curve for 24 h (AUC) of ≥400 using population pharmacokinetic (PK) modeling. Secondarily, determination of the relationship between serum creatinine (SCR) and vancomycin clearance in neonates was done. A retrospective population PK study was designed and included pediatric patients ≤180 days old who had received vancomycin and had a serum vancomycin concentration sampled.
View Article and Find Full Text PDFAim: There are few reliable estimates of the half-lives of maternal antibodies to the antigens found in the primary series vaccines. We aimed to calculate the half-lives of passively acquired diphtheria, tetanus and pertussis (DTP) antibodies in infants. We aimed to determine whether decay rates varied according to country, maternal age, gestational age, birthweight, World Bank income classifications, or vaccine received by the mother during pregnancy.
View Article and Find Full Text PDFVaricella and measles infection represents a significant source of morbidity and mortality for pediatric LT recipients. We evaluated the prevalence and correlates of post-transplant immunity in pediatric LT recipients previously immunized against measles (n = 72) and varicella (n = 67). Sixteen of seventy-two (22%) patients were measles non-immune, and 42/67 (63%) were varicella non-immune after LT.
View Article and Find Full Text PDFBackground: Pertussis vaccination has reduced the number of notified cases in industrialized countries from peak years by more than 95%. The effect of recently recommended adult and adolescent vaccination strategies on infant pertussis depends, in part, on the proportion of infants infected by adults and adolescents. This proportion, however, remains unclear, because studies have not been able to determine the source case for 47%-60% of infant cases.
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