Publications by authors named "Floor Kerstens"
Article Synopsis
- The 'MHC-I-opathy' concept refers to a group of inflammatory diseases linked to the major histocompatibility complex class I, with recognized conditions including spondyloarthritis and psoriasis, all associated with specific genetic variants.
- There is a significant challenge in understanding and treating these disorders due to differences in patient symptoms and insufficient research on the MHC-I pathway.
- The text advocates for a collaborative approach involving diverse medical and research disciplines to standardize disease definitions, explore genetic factors, and improve therapeutic strategies, ultimately aiming to enhance patient care.
Objective: To investigate the differential diagnostic spectrum in patients with suspected Behçet's syndrome (BS) in low prevalence regions. In addition, the number of patients fulfilling the ICBD criteria despite not having BS was evaluated.
Methods: This retrospective analysis was performed in two referral centres for BS.
Objectives: Behçet's syndrome (BS) is a systemic vasculitis with heterogeneous clinical presentation and a relapsing disease course. The International Study Group (ISG) criteria are most often used for classification. A significant proportion of patients is classified as probable BS because they do not fulfil the criteria at initial presentation.
View Article and Find Full Text PDFObjectives: To assess adherence to published guidelines for the treatment of Behçet's syndrome (BS) in two geographic areas.
Methods: We extracted guideline statements from the 2008 EULAR recommendations. Adherence to these statements was evaluated retrospectively in both New York (USA) and Amsterdam (The Netherlands), by reviewing records from patients fulfilling the ISG criteria.
Objective: Gradual local heating of the skin induces a largely NO-mediated vasodilatation. However, use of this assessment of microvascular health is limited because little is known about its reproducibility.
Methods: Healthy volunteers (n = 9) reported twice to the laboratory.