Publications by authors named "Fleur Darre"
Most people in the world (∼90%) are infected by the Epstein-Barr virus (EBV), which establishes itself permanently in B cells. Infection by EBV is related to a number of diseases including infectious mononucleosis, multiple sclerosis, and different types of cancer. So far, only seven complete EBV strains have been described, all of them coming from donors presenting EBV-related diseases.
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- CNVs (copy number variants) are important for understanding human evolution, but we lack data on primate CNVs.
- We conducted genomic hybridizations on bonobos, chimpanzees, gorillas, and orangutans to identify and compare CNV locations and frequencies among these species and humans.
- Our findings reveal different selective pressures in CNVs across lineages, with gorillas showing evidence of purifying selection, while orangutans show signs of positive selection, and bonobos and chimpanzees exhibit relaxed selection due to a past duplication event.
'Orang-utan' is derived from a Malay term meaning 'man of the forest' and aptly describes the southeast Asian great apes native to Sumatra and Borneo. The orang-utan species, Pongo abelii (Sumatran) and Pongo pygmaeus (Bornean), are the most phylogenetically distant great apes from humans, thereby providing an informative perspective on hominid evolution. Here we present a Sumatran orang-utan draft genome assembly and short read sequence data from five Sumatran and five Bornean orang-utan genomes.
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