Small molecule APOL1 inhibitors as a precision medicine approach for APOL1-mediated kidney disease.

Chronic kidney disease affects ~10% of people worldwide and there are no disease modifying therapeutics that address the underlying cause of any form of kidney disease. Genome wide association studies have identified the G1 and G2 variants in the apolipoprotein L1 (APOL1) gene as major contributors to a subtype of proteinuric kidney disease now referred to as APOL1-mediated kidney disease (AMKD). We hypothesized that inhibition of APOL1 could have therapeutic potential for this genetically-defined form of kidney disease.

Investigating the methods and characteristics of the trafficking of performance and image enhancing drugs in Australia.

Introduction: Using case law, the aims of this study were to document the methods for trafficking of performance and image-enhancing drugs (PIED) into Australia, and the characteristics of individuals and groups involved.

Methods: Data was collected from judges' sentencing comments. Searches were conducted using the Australasian Legal Information Institute database across all states in Australia, for the period of January 2010 to December 2021.

Certification of New Standard Reference Material 2806b Medium Test Dust in Hydraulic Fluid.

A new material has been certified to become Standard Reference Material (SRM) 2806b - Medium Test Dust in Hydraulic Fluid. SRM 2806b consists of trace polydisperse, irregularly shaped mineral dust particles suspended in hydraulic fluid. The certified values of SRM 2806b are the projected area circular-equivalent diameters of the collected dust particles from the hydraulic fluid.

Selecting among competing alternatives: selection and retrieval in the left inferior frontal gyrus.

It has been widely argued that the left inferior frontal gyrus (LIFG) is involved in the control of retrieval of information from long-term memory. Recent claims that the LIFG is involved in selecting among semantic alternatives have been challenged on the grounds that the manipulation of selection demands may have been confounded with controlled retrieval. The current study used an event-related functional magnetic resonance paradigm to re-examine the possibility that LIFG activation is involved in selection processes.

Neural processing of nouns and verbs: the role of inflectional morphology.

Dissociations of nouns and verbs following brain damage have been interpreted as evidence for distinct neural substrates underlying different aspects of the language system. Some neuroimaging studies have supported this claim by finding neural differentiation for nouns and verbs [Brain 122 (1999) 2337] while others have argued against neural specialisation [Brain 119 (1996) 159; Brain 124 (2001) 1619]. We suggest that one reason why these inconsistencies may have arisen is because the morphological structure of nouns and verbs has been ignored.

Do semantic categories activate distinct cortical regions? Evidence for a distributed neural semantic system.

A key issue in cognitive neuroscience concerns the neural representation of conceptual knowledge. Currently, debate focuses around the issue of whether there are neural regions specialised for the processing of specific semantic attributes or categories, or whether concepts are represented in an undifferentiated neural system. Neuropsychological studies of patients with selective semantic deficits and previous neuroimaging studies do not unequivocally support either account.

Objects and their actions: evidence for a neurally distributed semantic system.

An influential model of conceptual knowledge claims that objects are represented in a distributed network of cortical areas that store information about different types of attributes, such as form, colour, and motion (A. Martin et al., 2000, in: The Cognitive Neurosciences, 2nd ed.

Amino acid assimilation and respiration by attached and free-living populations of a marinePseudomonas sp.

The uptake kinetics of leucine and the assimilation and respiration of leucine, glycine, glutamate and arginine by a marinePseudomonas sp. was evaluated to determine whether the uptake and efficiency of substrate utilization of free-living bacteria differed from that of bacteria associated with surfaces. Bacteria were allowed to attach to plastic substrata with known hydrophilicities, as measured by advancing water contact angle (θ A); these were Thermanox, poly(vinylidene fluoride), poly(ethelene) and poly(tetrafluoroethylene).

Amino Acid assimilation and electron transport system activity in attached and free-living marine bacteria.

Amino acid assimilation and electron transport system activity of a marine Pseudomonas sp. was evaluated to determine whether the activity of bacteria attached to solid surfaces differed from that of free-living bacteria or bacteria which had been attached but subsequently desorbed from the substratum (detached bacteria). Bacteria were allowed to attach to glass and to a range of plastic surfaces (Thermanox, polyvinylidene fluoride, polyethylene, polytetrafluoroethylene).

Selected cardiac and metabolic responses to pseudoephedrine with exercise.

Pseudoephedrine hydrochloride was evaluated at two dosage levels in six normal healthy males, at rest and during submaximal exercise. Although there appeared to be a dose-related rise and during submaximal exercise. Although there appeared to be a dose-related rise in resting heart rate, it was not statistically significant.