- PRAME immunohistochemistry is effective for differentiating between malignant thin melanomas and benign melanocytic nevi, with specific staining patterns observed in each.
- In the study, 26% of melanomas exhibited strong PRAME staining (4+), while none of the nevi reached this level, indicating a clear distinction in PRAME expression.
- Lowering the positivity threshold for PRAME staining can enhance sensitivity for detecting thin melanomas without significantly compromising specificity, suggesting a more nuanced approach may be beneficial.
Walnuts ( L.) are an important source of ellagitannins. They have been linked to positive effects on many pathologies, including cardiovascular disorders, neurodegenerative syndromes, and cancer.