Publications by authors named "Flavio Sampaio Domingues"

Introduction: Familial Cerebral Cavernous Malformations (fCCMs) are rare, hereditary conditions characterized by multiple central nervous system lesions. Despite their rarity, CCMs can cause significant clinical challenges when symptomatic, manifesting as seizure and symptomatic hemorrhage (CASH). Guidelines suggest neurosurgical intervention for symptomatic or previously symptomatic lesions, while conservative management is recommended for new-onset epilepsy.

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Article Synopsis
  • The meta-analysis explores the effectiveness of surgical intervention versus conservative management for symptomatic cerebral cavernous malformations (CCMs), tackling the challenges of uncertain clinical management due to limited trial data.
  • Results indicate that while surgical intervention might lead to more events (neurological deficits or bleeding) in the long run, observational management showed a longer mean time before these events occurred.
  • The study concludes that observational management could offer better long-term outcomes and emphasizes the necessity for more research, including randomized controlled trials, to improve treatment approaches for CCMs.
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  • Cavernomas are genetic vascular lesions located in the central nervous system that may require alternative treatment options, like Gamma Knife stereotactic radiosurgery (GKSRS), when found in critical areas where surgery is not advisable.
  • A systematic review and meta-analysis of seven studies involving 1,071 patients revealed that GKSRS had an 89.8% events-free rate at two years and 71.3% at ten years following treatment.
  • The findings suggest that GKSRS is a promising alternative for managing symptomatic cavernomas, but further research is necessary to strengthen these conclusions.
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Neurocysticercosis (NCC) is an endemic disease and important public health problem in some areas of the World and epilepsy is the most common neurological manifestation. Multiple intracranial lesions, commonly calcified, are seen on cranial computed tomography (CT) in the chronic phase of the disease and considered one of the diagnostic criteria of the diagnosis. Magnetic resonance imaging (MRI) is the test that better depicts the different stages of the intracranial cysts but does not show clearly calcified lesions.

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