Aeromedical interhospital transport of an adult with COVID-19 on extracorporeal membrane oxygenation: case report.

Objective: To describe the experience of aeromedical interhospital transport of an adult patient with severe hypoxemic respiratory failure due to SARS-CoV-2, on extracorporeal membrane oxygenation.

Method: This is a case report, guided by the tool Case Report Guidelines, with a descriptive approach. Data were collected from the digital medical record and field notes after the approval by the Institution and the Human Research Ethics Committee.

Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice.

Tumor necrosis factor (TNF)-alpha plays an important role in the mediation of reperfusion-induced tissue injury and lethality. Here, we assessed the effects of PKF242-484 and PKF241-466, two dual inhibitors of TNF-alpha converting enzyme (TACE) and matrix metalloproteinases (MMPs), in a model of ischemia and reperfusion injury in mice. Reperfused animals that received PKF242-484 or PKF241-466 treatment had a dose-dependent reduction of TNF-alpha concentrations in serum.

Initial and delayed onset of acute respiratory failure: factors associated with development and outcome.

In a prospective observational study of 1038 adult admissions to a 31-bed medical/surgical intensive care unit (ICU), acute respiratory failure (ARF, defined as a Pao(2)/Fio(2) ratio 48 h after ICU admission) in 49 (16%). On admission, the cardiovascular sequential organ failure assessment (SOFA) score was higher in initial than in delayed onset ARF (1.

Body temperature alterations in the critically ill.

Objective: To determine the incidence of body temperature (BT) alterations in critically ill patients, and their relationship with infection and outcome.

Design: Prospective, observational study. SETTING.

Infection Probability Score (IPS): A method to help assess the probability of infection in critically ill patients.

Objective: To develop a simple score to help assess the presence or absence of infection in critically ill patients using routinely available variables.

Design: Observational study of a prospective cohort of patients divided into a developmental set (n = 353) and a validation set (n = 140).

Setting: Department of intensive care at an academic tertiary care center.

C-reactive protein levels correlate with mortality and organ failure in critically ill patients.

Study Objectives: C-reactive protein (CRP) is an acute-phase protein, the blood levels of which increase rapidly in response to infection, trauma, ischemia, burns, and other inflammatory conditions. Although used frequently in the ICU as a sepsis marker, the relation of CRP levels to organ damage is not well known. This study assessed the association between early serum CRP concentrations and the development of organ failure and mortality in ICU patients.

The Multiple Organ Dysfunction Score (MODS) versus the Sequential Organ Failure Assessment (SOFA) score in outcome prediction.

Objective: To compare outcome prediction using the Multiple Organ Dysfunction Score (MODS) and the Sequential Organ Failure Assessment (SOFA), two of the systems most commonly used to evaluate organ dysfunction in the intensive care unit (ICU).

Design: Prospective, observational study.

Setting: Thirty-one-bed, university hospital ICU.