Publications by authors named "Flaviane N Silva"
Article Synopsis
- Colorectal cancer (CRC) is a common and serious cancer in the U.S., affecting about 135,000 people each year and causing around 50,000 deaths.
- Some people with a genetic disease called autosomal dominant polycystic kidney disease (ADPKD), which affects kidneys, might have a lower chance of getting CRC.
- Studies using mice show that when the gene PKD1 is missing, it can reduce the risk and growth of CRC, possibly helping us understand how genetics influence this type of cancer.
The Aurora kinases (AURKA and AURKB) have attracted attention as therapeutic targets in head and neck squamous cell carcinomas. Aurora kinases were first defined as regulators of mitosis that localization to the centrosome (AURKA) and centromere (AURKB), governing formation of the mitotic spindle, chromatin condensation, activation of the core mitotic kinase CDK1, alignment of chromosomes at metaphase, and other processes. Subsequently, additional roles for Aurora kinases have been defined in other phases of cell cycle, including regulation of ciliary disassembly and DNA replication.
View Article and Find Full Text PDFStudies related to the immunobiological aspects of an Ascaris spp. infection are still scarce, especially those that aim to elucidate the early events of the immune response. In this study, we demonstrated a novel standardized method for early experimental Ascaris infection, providing additional information about the infectivity of eggs embryonated in vitro as well as the influence of host age on development of the infection.
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