Effect of Synadenium grantii and its isolated compound on dysmenorrhea behavior model in mice.

Objective: This study aimed to evaluate the effects of the methanol extract of Synadenium grantii Hook f. stems and its main isolated compound Query3,4,12,13-tetraacetylforbol-20-phenylacetate (1) on experimental dysmenorrhea in mice.

Methods: Female Swiss mice (n = 6-15) of 6-8 weeks old were used, selected according to the period of the estrous cycle.