Publications by authors named "Flavia Sacilotto Donaires"
Background: Resistance to apoptosis in chronic myeloid leukemia (CML) is associated with constitutive tyrosine kinase activity of the Bcr-Abl oncoprotein. The deregulated expression of apoptosis-related genes and alteration in epigenetic machinery may also contribute to apoptosis resistance in CML. Tyrosine kinase inhibitors target the Bcr-Abl oncoprotein and are used in CML treatment.
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- Myelodysplastic syndromes (MDS) are blood disorders linked to ineffective blood cell production and can lead to leukemia, with SF3B1 gene mutations often found in MDS subtypes that show ring sideroblasts.
- In a study of 91 Brazilian MDS patients, researchers screened for mutations in the SF3B1 gene and found that 7% of the patients (6 individuals) with ring sideroblasts had heterozygous mutations.
- This research confirms the strong association between SF3B1 mutations and the presence of ring sideroblasts in MDS, marking the first such analysis in Brazilian patients.