Publications by authors named "Flavia P Albuquerque"
Although there are reports that polyphenol resveratrol (Rsv) may cause muscle hypertrophy in basal conditions and attenuate muscle wasting in catabolic situations, its mechanism of action is still unclear. Our study evaluated the ex vivo effects of Rsv on protein metabolism and intracellular signaling in innervated (sham-operated; Sham) and 3-day sciatic denervated (Den) rat skeletal muscles. Rsv (10-4 M) reduced total proteolysis (40%) in sham muscles.
View Article and Find Full Text PDFAlpha thalassemia, but not β-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort.
Ann Hematol
April 2021
Alpha thalassemia and beta-globin haplotype are considered classical genetic disease modifiers in sickle cell anemia (SCA) causing clinical heterogeneity. Nevertheless, their functional impact on SCA disease emergence and progression remains elusive. To better understand the role of alpha thalassemia and beta-globin haplotype in SCA, we performed a retrospective study evaluating the clinical manifestations of 614 patients.
View Article and Find Full Text PDFInfluence of UGT1A1 promoter polymorphism, α-thalassemia and β haplotype in bilirubin levels and cholelithiasis in a large sickle cell anemia cohort.
Ann Hematol
April 2021
Article Synopsis
- Hyperbilirubinemia in sickle cell anemia (SCA) patients can lead to gallstone (cholelithiasis) formation, with some evidence linking this to genetic variations like UGT1A1 promoter polymorphisms, which are associated with Gilbert syndrome (GS).
- A study analyzed 913 SCA patients to investigate the relationship between UGT1A1 alleles, alpha thalassemia, and beta haplotypes with bilirubin levels and the presence of gallstones. Results showed that GS patients had higher bilirubin levels and an earlier onset of gallstones compared to those without it.
- The research found that low fetal hemoglobin levels and a normal alpha thalassemia
Article Synopsis
- The ethanolic extract of EEMn was tested on diabetic rats for its potential health benefits, focusing on its effects on blood sugar and cholesterol levels.
- EEMn (400 mg/kg) significantly lowered fasting and post-meal blood glucose, improved glucose tolerance, and decreased harmful lipids in diabetic rats.
- Additionally, the study found that EEMn reduced oxidative stress markers in the liver and contained beneficial flavonoids like rutin and isoquercetin, suggesting it may offer protective cardiovascular effects.