Publications by authors named "Flavia Fernandes Moreira-Leite"
Article Synopsis
- Trypanosoma brucei is a key unicellular parasite, but understanding its biology is tough due to the unknown functions of about half its proteins.
- Researchers mapped the locations of 89% of the T. brucei proteins using fluorescence microscopy and created a resource called TrypTag.
- This resource reveals important organelle adaptations for parasitism, provides a detailed analysis of the eukaryotic flagellum, and helps identify novel cellular structures and processes throughout the cell cycle.
The 9 + 2 axoneme structure of the motile flagellum/cilium is an iconic, apparently symmetrical cellular structure. Recently, asymmetries along the length of motile flagella have been identified in a number of organisms, typically in the inner and outer dynein arms. Flagellum-beat waveforms are adapted for different functions.
View Article and Find Full Text PDFTrypanosomes and Leishmanias are important human parasites whose cellular architecture is centred on the single flagellum. In trypanosomes, this flagellum is attached to the cell along a complex flagellum attachment zone (FAZ), comprising flagellar and cytoplasmic components, the integrity of which is required for correct cell morphogenesis and division. The cytoplasmic FAZ cytoskeleton is conspicuously associated with a sheet of endoplasmic reticulum termed the 'FAZ ER'.
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