Publications by authors named "Flavia Eichemberger Rius"
Article Synopsis
- Epigenetic changes, such as DNA methylation, play a crucial role in the development and progression of melanoma, alongside genetic mutations.*
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- The study aimed to discover how methylation of promoter and gene body regions affects gene expression, linking these changes to various stages of melanoma progression using a linear mouse model.*
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- Key genes related to tumor growth (Adcy3) and metastasis (Inpp4b) were identified, and the findings showed a correlation between the mouse model's results and clinical data from melanoma patient cohorts, suggesting possible prognostic markers.*
Article Synopsis
- Despite improvements in treatment, melanoma still often leads to poor patient outcomes, and there is a lack of effective biological models to study its progression.
- Researchers analyzed the gene expression profiles of various melanoma cell lines representing different stages of the disease, finding distinct gene expression patterns linked to cell differentiation and mesenchymal transitions.
- The study identified several genes that could serve as prognostic markers for melanoma progression, enhancing our understanding of the disease and suggesting potential new drug targets.
Article Synopsis
- The study highlights the connection between the aggressive nature of melanoma and its ability to spread via blood vessel (angiogenesis) and lymphatic vessel growth (lymphangiogenesis).
- Researchers identified key factors, particularly VEGFC, ANGPT2, and SIX1, that are linked to melanoma's severity and found that blocking the vascular growth pathways can reduce tumor development.
- Data analysis revealed that the expression levels of specific angiogenic factors and their associated genetic methylation patterns can serve as independent prognostic indicators for melanoma patients, suggesting these could be valuable biomarkers for predicting patient outcomes.
