Publications by authors named "Flavia Eduarda Vidal Barbosa"
Dioclea violacea lectin has potent in vitro leishmanicidal activity against Leishmania infantum via carbohydrate recognition domain.
Flávia Eduarda Vidal Barbosa Dimas Batista de Lima Ana Lúcia Estevam Dos Santos Valéria Carlos de Sousa Rita de Cássia Viana Carvalho
Int J Biol Macromol
September 2024
Article Synopsis
- Existing leishmaniasis treatments have limitations and side effects, prompting the exploration of new alternatives like the lectin DVL from Dioclea violacea seeds.
- DVL showed significant leishmanicidal effects against Leishmania infantum in vitro, inducing reactive oxygen species and damaging the parasite's membrane, with an effective concentration of 49.37 μg/mL.
- DVL enhanced the effectiveness of traditional drugs like amphotericin B and glucantime, reduced macrophage infection rates, and exhibited no toxicity in healthy cells, indicating its potential as a treatment for visceral leishmaniasis.
Concanavalin A, lectin from Canavalia ensiformis seeds has Leishmania infantum antipromastigote activity mediated by carbohydrate recognition domain.
Ana Lúcia Estevam Dos Santos Racquel Oliveira Silva Souza Flávia Eduarda Vidal Barbosa Maria Helena Cruz Dos Santos Yasmim Alencar Grangeiro
Chem Biol Interact
August 2024
Leishmaniases, caused by Leishmania parasites, are widespread and pose significant health risks globally. Visceral leishmaniasis (VL) is particularly prevalent in Brazil, with high morbidity and mortality rates. Traditional treatments, such as pentavalent antimonials, have limitations due to toxicity and resistance.
View Article and Find Full Text PDF