Ruthenium(II) complexes of curcumin and β-diketone derivatives: effect of structural modifications on their cytotoxicity.

Ruthenium(II) complexes (-) with the general formula [Ru(O-O)(PPh)(bipy)]PF bearing two triphenylphosphine (PPh), bipyridine (bipy) and a series of natural and synthetic β-diketones (O,O) ligands were synthesized and characterized using various analytical techniques. The interaction between the complexes and DNA (CT-DNA) was investigated and demonstrated a weak interaction. The cytotoxicity of the complexes was investigated against breast cancer cells (MDA-MB-231 and MCF-7), lung cancer cells (A549), cisplatin-resistant ovarian cancer cells (A2780), as well as non-tumour lung (MRC-5) and non-tumour breast (MCF-10A) cell lines.