Publications by authors named "Flavia Chagas Costa"
Gene expression profiles of erythroid precursors characterise several mechanisms of the action of hydroxycarbamide in sickle cell anaemia.
Flávia Chagas Costa Anderson Ferreira da Cunha André Fattori Tarcísio de Sousa Peres Gustavo Gilson Lacerda Costa Fernando Ferreira Costa
Br J Haematol
January 2007
Article Synopsis
- Hydroxycarbamide (HC) is known to raise fetal hemoglobin levels and alleviate symptoms in patients with sickle cell anemia (SCA), but its exact mechanism is not fully understood.
- An analysis of gene expression in bone marrow cells from an SCA patient revealed 147 differentially expressed transcripts after HC treatment.
- Some of these transcripts are linked to transcriptional and translational regulation, indicating they could be crucial in improving SCA symptoms and might lead to new treatment targets.