Publications by authors named "Flavia C de Aquino Xavier"
Background: Transcription factors are important in the epithelial-mesenchymal transition process and are possibly related to the development of a more invasive tumor phenotype. Thus, the objective of this study was to analyze the expression and identify the localization of cellular markers related to the epithelial-mesenchymal transition process in salivary gland tumors.
Study Design: The expression and localization of E-CADERIN, N-CADERIN, SLUG, SNAIL, and TWIST were evaluated, using immunohistochemistry, in 48 salivary gland tumors, being 17 pleomorphic adenomas (PA), 14 adenoid cystic carcinomas (ACC), and 17 mucoepidermoid carcinomas (MEC).
Background: Three years after the first confirmed COVID-19 case in Brazil, the outcomes of Federal government omissions in managing the crisis and anti-science stance heading into the pandemic have become even more evident. With over 36 million confirmed cases and nearly 700 000 deaths up to January 2023, the country is one of the hardest-hit places in the world. The lack of mass-testing programs was a critical broken pillar responsible for the quick and uncontrolled SARS-CoV-2 spread throughout the Brazilian population.
View Article and Find Full Text PDFSalivary gland neoplasms represent an important group of cancers in the head and neck and myoepithelial cells play a key role on the development these tumors. This study evaluated the distribution of mast cells and related proteins (PAR-2, TGFβ1, IL-6) to the myofibroblastic differentiation in malignant tumors of salivary glands with and without myoepithelial differentiation. Immunohistochemical assessement for tryptase mast cells, SMA, PAR-2, TGFβ1, IL-6 was performed in 10 cases of polymorphous low-grade adenocarcinoma, 14 cases of mucoepidermoid carcinoma (MEC) and 10 cases of adenoid cystic carcinoma.
View Article and Find Full Text PDFIntroduction: Mesenchymal stem cells (MSCs) are characterized by the potential to differentiate into multiple cell lineages, high proliferation rates, and self-renewal capacity, in addition to the ability to maintain their undifferentiated state. These cells have been identified in physiological oral tissues such as pulp tissue, dental follicle, apical papilla and periodontal ligament, as well as in pathological situations such as chronic periapical lesions (CPLs). The criteria used for the identification of MSCs include the positive expression of specific surface antigens, with CD73, CD90, CD105, CD44, CD146, STRO-1, CD166, NANOG and OCT4 being the most specific for these cells.
View Article and Find Full Text PDFIntroduction: Lugol is helpful in identifying early second primary tumors (SPTs) during oroscopy and pharyngoscopy, but this technique has not been assessed during follow-up visits with these patients.
Aim: The aim of this study is to describe the use of Lugol (a low-cost method) to diagnose SPTs in the oral cavity and oropharynx.
Methods: Patients treated for squamous cell carcinoma of the head and neck were randomly assigned to two groups.
The aim of this study was to characterize the profile of the proteins involved in the Hedgehog signaling pathway to aid in the understanding of the pathogenesis of oral epithelial dysplasia (OED). The proteins SHH, PTCH1, HHIP, SUFU, GLI1, and cyclin D1 were evaluated by immunohistochemistry in 25 cases of OED, 4 of non-neoplasic oral mucosa, 8 of inflammatory fibrous hyperplasia and 5 of hyperkeratosis. SHH proteins were predominant in OED cases.
View Article and Find Full Text PDFHomeobox genes are a family of transcription factors that play a pivotal role in embryogenesis. Prospero homeobox 1 (PROX1) has been shown to function as a tumor suppressor gene or oncogene in various types of cancer, including oral squamous cell carcinoma (OSCC). We have previously identified PROX1 as a downregulated gene in OSCC.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted on 223 adult Kiriri Indians in Northeast Brazil to assess the prevalence of oral mucosal lesions and their associated risk factors.
- Results showed that 22.4% of participants had mucosal lesions, with the most common types being fistulae (6.2%) and traumatic ulcers (4.48%).
- The study found that older age (≥ 35 years) and lower education levels (less than 9 years) were significantly linked to the presence of these lesions, highlighting the need for targeted public health programs to improve oral health in this community.
Article Synopsis
- Lichen sclerosus (LS) is a rare skin and mucous membrane condition that can affect the mouth, with unclear causes often linked to autoimmune and genetic factors.
- A 47-year-old man exhibited an unusual case of oral LS characterized by a white plaque with red patches in the mouth, without other skin conditions present.
- Immunohistochemical analyses revealed changes in tissue components, such as altered collagen and elastin levels, suggesting disruptions in tissue structure and potential involvement of immune cells in the condition's development.
Article Synopsis
- The study investigated the characteristics and components of oral mucoceles, analyzing 100 cases for clinicopathological features and 32 cases for immunohistochemical markers.
- Oral mucoceles commonly appear as nodules or blisters, primarily in the lower lip of younger males, with sizes ranging from 0.4 to 3.0 cm.
- Significant relationships were found between mast cells and MMP-1, as well as between macrophages and MMP-1, indicating their role in the tissue remodeling process of these lesions.