Publications by authors named "Flavia B Garcez"
Objective: Malnutrition is one of the most threatening conditions in geriatric populations. The gut microbiota has an important role in the host's metabolic and muscular health: however, its interplay with disease-related malnutrition is not well understood. We aimed to identify the association of malnutrition with the gut microbiota and predict clinical outcomes in hospitalized acutely ill older adults.
View Article and Find Full Text PDFDelirium is a common, serious, and often preventable neuropsychiatric emergency mostly characterized by a disturbance in attention and awareness. Systemic insult and inflammation causing blood-brain-barrier (BBB) damage and glial and neuronal activation leading to more inflammation and cell death is the most accepted theory behind delirium's pathophysiology. This study aims to evaluate the relationship between brain injury biomarkers on admission and delirium in acutely ill older patients.
View Article and Find Full Text PDFArticle Synopsis
- The study explored the connection between gut microbiota and the occurrence of delirium in older adults admitted to the hospital, involving 133 participants aged 65 and older.
- Delirium was identified in 29% of participants, with findings showing that higher gut microbiota diversity (more types and amounts of microorganisms) correlated with a lower risk of developing delirium.
- The research indicates that certain bacteria linked to inflammation and neurotransmitter modulation were more prevalent in those who experienced delirium, suggesting potential avenues for future research in delirium prevention and treatment.
Unlabelled: Dementia is a cause of disability among older adults. Accessing advanced dementia prognosis is a challenge.
Objective: The objective of this study was to evaluate the accuracy of the Charlson and Carey indexes in predicting 3-year survival of older adults with advanced dementia.
Background & Aims: Acutely ill older adults are at higher risk of malnutrition. This study aimed to explore the applicability and accuracy of the GLIM criteria to diagnose malnutrition in acutely ill older adults in the emergency ward (EW).
Methods: We performed a retrospective secondary analysis, of an ongoing cohort study, in 165 participants over 65 years of age admitted to the EW of a Brazilian university hospital.
Background: Frailty screening using the Clinical Frailty Scale (CFS) has been proposed to guide resource allocation in acute care settings during the pandemic. However, the association between frailty and coronavirus disease 2019 (COVID-19) prognosis remains unclear.
Objectives: To investigate the association between frailty and mortality over 6 months in middle-aged and older patients hospitalized with COVID-19 and the association between acute morbidity severity and mortality across frailty strata.
Background: Although frailty has been associated with atypical manifestations of infections, little is known about COVID-19 presentations in hospitalized frail patients. We aimed to investigate the association between age, frailty, and clinical characteristics of COVID-19 in hospitalized middle-aged and older adults.
Method: Longitudinal observational study comprising 711 patients aged ≥50 years consecutively admitted to a university hospital dedicated to COVID-19 severe cases, between March and May 2020.
Background: Although coronavirus disease 2019 (COVID-19) disproportionally affects older adults, the use of conventional triage tools in acute care settings ignores the key aspects of vulnerability.
Objective: This study aimed to determine the usefulness of adding a rapid vulnerability screening to an illness acuity tool to predict mortality in hospitalised COVID-19 patients.
Design: Cohort study.
Background: Little is known about the association between acute mental changes and adverse outcomes in hospitalized adults with COVID-19.
Objectives: To investigate the occurrence of delirium in hospitalized patients with COVID-19 and explore its association with adverse outcomes.
Design: Longitudinal observational study.
Objective: To investigate the association between impaired arousal on admission and 30-day mortality in acutely ill older adults.
Design: Retrospective cohort study.
Setting And Participants: Patients age +65 years admitted to the geriatric ward of a tertiary university hospital from 2010 to 2018 in Sao Paulo, Brazil.
Objectives: to investigate the association between delirium occurrence in acutely ill older adults and incident dementia after hospital discharge.
Methods: retrospective cohort study examining acutely ill older adults aged +60 years and consecutively admitted to the geriatric ward of a tertiary university hospital from 2010 to 2016. Inclusion criteria were absence of baseline cognitive decline on admission and documented clinical follow-up of +12 months after discharge.
Due to the high prevalence of anxiety disorders and hypertension comorbidity in the general population, the establishment of anxiety as a risk factor for elevated blood pressure, or the reverse, is of great relevance. In this context, animal models can be of great scientific value, as they permit the control of several variables. Bearing this in mind, the influence of anxiety, not as a state, but as a personality trait (trait anxiety), on blood pressure elevation and vice versa were investigated for the first time in rats, using the free-exploratory paradigm (FEP).
View Article and Find Full Text PDFObjective: To evaluate the hearing status of growth hormone (GH)-naive adults with isolated GH deficiency (IGHD) belonging to an extended Brazilian kindred with a homozygous mutation in the GH-releasing hormone receptor gene.
Study Design: Cross-sectional.
Setting: Divisions of Endocrinology and Otorhinolaryngology of the Federal University of Sergipe.
Article Synopsis
- Chronotropic incompetence (CI) is linked to increased mortality risk and coronary artery disease, yet its underlying mechanisms are unclear.
- A study analyzed 610 patients undergoing exercise echocardiography, dividing them into two groups based on their heart rate response during the test: those with CI (Chl) and those without (ChC).
- Findings revealed that patients with CI exhibited more symptoms like dyspnoea and hypertension, poorer exercise tolerance, and significant left ventricle dysfunction, particularly related to severe right coronary artery blockages.