Publications by authors named "Fitzpatrick J"

Nephrology nurses working in hemodialysis units face unique challenges managing multiple patients - an experience often contributing to higher levels of burnout and stress, and potentially lower job satisfaction and retention rates, exacerbating the existing nursing shortage in dialysis settings. Targeted strategies are essential to improve job satisfaction. In this study, we explored the relationship between emotional intelligence and job satisfaction among nephrology nurses working in acute and chronic hemodialysis settings.

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Isolation caused by anthropogenic habitat fragmentation can destabilize populations. Populations relying on the inflow of immigrants can face reduced fitness due to inbreeding depression as fewer new individuals arrive. Empirical studies of the demographic consequences of isolation are critical to understand how populations persist through changing conditions.

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Introduction: Incontinence is commonly experienced by adults who receive care support in a residential facility or in their own home. These individuals are at risk of developing incontinence-associated dermatitis (IAD), which is caused by prolonged and repeated exposure of the skin to urine or faeces. An IAD manual was developed providing an evidence-based clinical algorithm and an e-learning training programme for the prevention and treatment of IAD.

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Natural language processing (NLP) is a burgeoning field of machine learning/artificial intelligence that focuses on the computational processing of human language. Researchers and clinicians are using NLP methods to advance the field of medicine in general and in heart failure (HF), in particular, by processing vast amounts of previously untapped semi-structured and unstructured textual data in electronic health records. NLP has several applications to clinical research, including dramatically improving processes for cohort assembly, disease phenotyping, and outcome ascertainment, among others.

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(partridgeberry; family Rubiaceae) is a creeping, understory plant native to eastern North America. The twinned, tubular flowers of this distylous plant are bright white and produce volatile organic compounds (VOCs). Partridgeberry has intermorph incompatibility and thus requires pollinators to move pollen from one morph to the other.

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Background: During the COVID-19 pandemic, care homes for older adults in England implemented isolation, social distancing and other restriction measures to help protect residents from contracting the virus. Little was known about the physical and psychological impacts that these measures would have upon residents and their relatives.

Aim: To explore the experiences of residents and their relatives of living restricted lives during the pandemic.

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In Brief: Female-male interactions shape fertilization outcomes, with broad implications from evolutionary biology to applied studies of fertility. This review discusses our current knowledge of female-male interactions at each stage of the fertilization process across externally and internally fertilizing species.

Abstract: Extensive research indicates that fertilization outcomes are shaped by individual female and male traits that reflect their intrinsic quality.

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Background: Older people living in care homes are at high risk of poor health outcomes and mortality if they contract coronavirus disease 2019. Protective measures include social distancing and isolation, although implementation is challenging.

Objectives: To explore the real-life experiences of social distancing and isolation in care homes for older people, and to develop a toolkit of guidance and resources.

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  • Breast cancer (BC) has distinct molecular subtypes influenced by different cell origins, yet the transcriptional networks for these subtypes are not well understood.
  • This study utilized advanced techniques on 61 samples from 37 BC patients to reveal how gene expression and chromatin accessibility connect BC subtypes to their likely cells of origin.
  • Key transcription factors BHLHE40 and KLF5 were found to play crucial roles in luminal and basal-like tumors, respectively, and exhausted CD8 T cells were linked to immune dysfunction in basal-like BC, showcasing the potential of single-cell level analysis in understanding cancer lineages.
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  • Job satisfaction is vital for healthcare professionals, especially nurses in psychiatric settings; understanding its influencing factors can enhance work environments and patient care quality.
  • A systematic review analyzed 16 eligible studies from a pool of 567, focusing on factors like interpersonal relationships, working conditions, and recognition as key drivers of nurse job satisfaction.
  • Differences were observed between psychiatric hospitals and diverse psychiatric settings, with the former emphasizing personal and psychosocial factors and the latter leaning towards external influences on job satisfaction.
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Background: The COVID-19 pandemic highlighted the negative impact of moral injury on nurses' well-being. However, there is a lack of research about generational differences among nurses, particularly on newer nurses who have been identified as having a higher rate of intention to leave.

Objective: This study examines generational differences among nurses on moral injury, well-being, resilience, and intention to leave their nursing position and profession.

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Background: We aimed to estimate the relative risk of mortality following a first positive SARS-CoV-2 test during the first, second, and third waves of the COVID-19pandemic in England by age, sex, and vaccination status, taking into account pre-existing health conditions and lifestyle factors.

Methods: We conducted a retrospective cohort study of all individuals registered with the National Health Service (NHS) in England from 1 March 2020 to September 2022. Data for all individuals were obtained and linked including primary care records, hospital admission episodes, SARS-CoV-2 test results, vaccinations, and death registrations.

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Inbreeding, or breeding with close relatives, often decreases individual fitness, but mate choice in many species can increase inbreeding risk. Inbreeding is more likely in species with limited dispersal, such as cooperative breeders where non-parental individuals-often offspring from previous broods-provide parental care and frequently breed close to home. We leverage 32 years of data from a population of Florida Scrub-Jays ( ), an avian cooperative breeder, to investigate whether mate choice, and its lifetime fitness outcomes, affects inbreeding tolerance.

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  • The Florida Scrub-Jay, a threatened bird species, serves as a significant model for studying evolution and ecology through extensive individual monitoring and genetic analysis.
  • Researchers created a detailed linkage map with 4,468 SNPs and a chromosome-level genome assembly for the species, totaling 1.33 Gb in length, which includes complete autosomes and sex chromosomes.
  • The high-quality genome assembly, with a BUSCO completeness score of 97.1%, features 17,964 identified protein-coding genes, which equips scientists with valuable resources for exploring the evolutionary dynamics of endangered species.
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To better understand the in-match fuelling practices of elite football players and compare against current guidelines, we quantified the carbohydrate, fluid, and caffeine intake of players from an English Premier League club ( = 22) during 90 min of competitive match-play. Mean carbohydrate intake across match-play was 17 ± 11 g.h with players demonstrating a preference towards CHO-containing fluids (58%) when compared with semi-solids (38%) and solids (14%), respectively.

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Hydrologic reconstructions from North America are largely unknown for the Middle Miocene. Examination of fungal palynomorph assemblages coupled with traditional plant-based palynology permits delineation of local, as opposed to regional, climate signals and provides a baseline for study of ancient fungas. Here, the Fungi in a Warmer World project presents paleoecology and paleoclimatology of 351 fungal morphotypes from 3 sites in the United States: the Clarkia Konservat-Lagerstätte site (Idaho), the Alum Bluff site (Florida), and the Bouie River site (Mississippi).

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  • * Results showed that lower SES was associated with worse FS and a higher likelihood of functional decline, with women consistently demonstrating poorer FS compared to men across different SES levels.
  • * Overall, the findings indicate that both lower SES and being female are significant risk factors for decreased functional status in patients with axSpA.
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Dietary patterns contribute to overall health and diseases of ageing but are understudied in older adults. As such, we first aimed to develop dietary indices to quantify Mediterranean Diet Score (MDS) utilisation and Ultra-processed Food (UPF) intake in a well-characterised cohort of relatively healthy community-dwelling older Australian adults. Second, we aimed to understand the relationship between these scores and the association of these scores with prevalent cardiometabolic disease and frailty.

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Alcohol consumption in pregnancy can affect genome regulation in the developing offspring but results have been contradictory. We employed a physiologically relevant murine model of short-term moderate prenatal alcohol exposure (PAE) resembling common patterns of alcohol consumption in pregnancy in humans. Early moderate PAE was sufficient to affect site-specific DNA methylation in newborn pups without altering behavioural outcomes in adult littermates.

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  • Nutritional studies are looking at how different diets can help prevent illnesses, especially inflammatory bowel disease (IBD), which affects the intestines.
  • Research shows that good quality diets may reduce the risk of Crohn's disease, but it's unclear how they affect ulcerative colitis.
  • Some diets like the Mediterranean diet might help with Crohn's disease, while eating a lot of ultra-processed foods could increase the risk, but we still need more studies to understand this better.
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Female genital schistosomiasis (FGS) and male genital schistosomiasis (MGS) are gender-specific manifestations of urogenital schistosomiasis. Morbidity is a consequence of prolonged inflammation in the human genital tract caused by the entrapped eggs of the waterborne parasite, Both diseases affect the sexual and reproductive health (SRH) of millions of people globally, especially in sub-Sahara Africa (SSA). Awareness and knowledge of these diseases is largely absent among affected communities and healthcare workers in endemic countries.

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