Rectal administration of tenoxicam for the treatment of rheumatoid arthritis and arthrosis.

Seventy-nine patients with arthrosis (40) or rheumatoid arthritis (39) were included in an open, non-comparative multicentric study. All the patients were treated by rectal route with a suppository form of tenoxicam (20 mg/day) during 6 weeks (in the first 3 days the dose was increased to 40 mg). The drug was administered once daily at evening.

Ro 12-0068 (tenoxicam) in the treatment of extra-articular inflammatory processes.

Tenoxicam is a thienothiazine derivative with anti-inflammatory properties. Due to its long half-life (40-90 hours) the drug can be administered once daily. One-hundred patients with tendinitis or bursitis were allocated in a double-blind study comparing 20 mg of tenoxicam to 20 mg of piroxicam.

Radiological assessment of knees in juvenile chronic arthritis (juvenile rheumatoid arthritis).

Radiological changes in the knees were assessed in those patients with juvenile chronic arthritis who still had evidence of knee involvement 5 years after onset of the disease. The patients were grouped according to age and mode of onset. Osteoporosis, modelling abnormalities, growth arrest lines and joint narrowing were found, but erosive change was less common.